Skip to main content

Studies of the mechanism of the anticonvulsant effect of delta-sleep-inducing peptide in conditions of increased oxygen tension

Neuroscience and Behavioral Physiology volume 27, pages 714–717 (1997)Cite this article

Abstract

Studies of the protective actions of three doses of delta-sleep-inducing peptide (DSIP) given at different times before barochamber compression of animals to an oxygen tension of 0.7 MPa showed that the optimum DSIP dose is 12 μg/100 g. Intraperitoneal administration of this dose of DSIP delayed the onset of generalized convulsive activity by a factor of 2–2.5 in animals exposed to an oxygen tension of 0.7 MPa and promoted normalization of the sleep-waking cycle within 24 h after exposure to hyperbaric oxygen (HBO), by creating an optimal balance between excitatory and inhibitory amino acid neuromediators.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. T. I. Bondarenko and M. G. Makletsova, “Quantitative determination of homocarnosine in cerebrospinal fluid and blood,” Lab. Delo.,34, No. 4 (1982).

    Google Scholar 

  2. T. I. Bondarenko, A. A. Krichevskaya, E. Yu. Krupnennikova, and I. I. Mikhaleva, “The effect of delta-sleep-inducing peptide on the state of erythrocyte membranes at low temperatures,” Fiziol. Zh. SSSR,71, No. 3, 279–282 (1985).

    PubMed  CAS  Google Scholar 

  3. A. A. Krichevskaya, A. I. Lukash, and Z. G. Bronovitskaya, The Biochemical Bases of Intoxication with Acids [in Russian], Rostov-on-Don (1980).

  4. G. F. Lakin, Biometrics [in Russian], Moscow (1990).

  5. A. M. Mendzheritskii, N. I. Uskova, and I. O. Chorayan, “The effect of delta-sleep-inducing peptide on the GABA system in the rat brain in hypokinesia,” Neirokhimiya,7, No. 2, 312–313 (1988).

    Google Scholar 

  6. A. M. Mendzheritskii, A. V. Lysenko, and I. I. Mikhaleva, “The effect of DSIP on the activity of proteolytic processes in the rat brain in hypokinesia,” Ukr. Biokhim. Zh.64, No. 5, 37 (1992).

    PubMed  CAS  Google Scholar 

  7. N. S. Popova, O. S. Adrianov, R. Veskov, et al., “The effect of delta-sleep-inducing peptide on intercenter integration in conditions of experimental epilepsy,” Byull. Éksp. Biol. Med.,108, No. 8, 147–150 (1989).

    CAS  Google Scholar 

  8. K. S. Raevskii and V. P. Georgiev, Mediator Amino Acids: Neuropharmacological Aspects [in Russian], Moscow (1986).

  9. A. A. Shandra, L. S. Godlevsky, A. M. Mazarati, and I. I. Mikhaleva, “On the role of DSIP in the mechanisms of pharmacological kindling,” in: DSIP: Theoretical and Applied Aspects, Rostov-on-Don (1991).

Download references

Authors
  1. A. M. Mendzheritskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Lysenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. I. Uskova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. A. Sametskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Laboratory of Neuropeptide Physiology and Biochemistry, A. B. Kogan Science Research Institute of Neurocybernetics, Rostov State University. Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 82, No. 1, pp. 59–64, January, 1996.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mendzheritskii, A.M., Lysenko, A.V., Uskova, N.I. et al. Studies of the mechanism of the anticonvulsant effect of delta-sleep-inducing peptide in conditions of increased oxygen tension. Neurosci Behav Physiol 27, 714–717 (1997). https://doi.org/10.1007/BF02461934

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02461934

Key words

  • Hyperoxia
  • convulsive activity
  • DSIP
  • neuromediators