Abstract
Thyroid hormone synthesis shows two important characteristics at each iodine organification step: iodine fixation to thyroglobulin tyrosyl residues in the vicinity of the thyroid cell microvilli, and the storage of thyroglobulin in the follicular lumen. In order to study the influence of kinetic parameters (chemical reactions, diffusion coefficient) and, of the structure (follicular radius and reactional space width) we have determined the impulsional response of a diffusion sphere exchanging matter with a compartment where the chemical reactions are taking place. This study gives the starting point of a mathematical model of hormonal secretion by a thyroid follicle. Moreover it suggests a simple way of estimating the thyroglobulin diffusion coefficient by the mean transit time determination. Finally, we discuss respectively the validity limits of a compartmental description of the model, and of a continuous description by an infinite sum of exponentials of a system where chemical reactions interfere with a storage process by diffusion.
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This work is part of a Ph.D. Thesis.
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Cantraine, F.R.L., Dewandre, B. Kinetics of the thyroid follicle lumen diffusion subsystem: Application to iodide accumulation by the thyroid folliclein vitro . Bltn Mathcal Biology 37, 301–321 (1975). https://doi.org/10.1007/BF02461448
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DOI: https://doi.org/10.1007/BF02461448