Abstract
Experiments on rhesus macaques were used to study the relationship between the characteristics of delayed visual differentiation and stimulus properties in conditions of pharmacological treatment with the m-cholinoreceptor blocker amizil, with the aim of identifying how modification of cholinergic structures affects different types of information. Disturbances to short-term memory for all stimuli consisted of reductions in the duration of retention and increases in motor reaction times, but occurred at different doses of the blocker: amizil at a dose of 0.3 mg/kg significantly decreased the retention duration for information relating to spatial relationships. Delayed discrimination of shape, contrast, and size worsened after treatment with amizil at a dose of 0.45–0.50 mg/kg, while decreases in the duration of short-term storage of information relating to color started after amizil doses of 0.6–0.8 mg/kg. It is suggested that the short-term memory system includes a set of neurophysiological mechanisms in which the cholinergic structures are organized differently and whose specific properties result in differences in the characteristics of short-term storage of different types of visual information.
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References
M. M. Bongard, The Question of Consciousness [in Russian], Nauka, Moscow (1967).
Yu. S. Borodkin and P. D. Shabanov, Neurochemical Mechanisms in the Fading of Memory Traces [in Russian], Nauka, Leningrad (1986).
K. N. Dudkin, Visual Perception and Memory [in Russian], Nauka, Leningrad (1985).
K. N. Dudkin, V. K. Kruchinin, Yu. V. Skryminskii, and I. V. Chueva, Methods for the Automation of Studies of the Neuronal Mechanisms of Behavior [in Russian], Nauka, Leningrad (1989).
K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “Involvement of cholinergic structures of the prefrontal and lower temporal cortex in visual recognition processes in monkeys,” Fiziol. Zh. im. I. M. Sechenova,79, No. 2, 31–42 (1993).
K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “Synchronization process in the mechanisms of short-term memory in monkeys: involvement of cholinergic and glutaminergic cortical structures,” Fiziol. Zh. im. I. M. Sechenova,81, No. 8, 128–134 (1995).
K. N. Dudkin and I. V. Chueva, “The relationship between learning characteristics in rhesus macaques and the properties of visual objects,” Fiziol. Zh. im. I. M. Sechenova,81, No. 1, 25–34 (1995).
K. N. Dudkin, I. V. Chueva, and I. V. Orlov, “The relationship between the characteristics of visual short-term memory in monkeys and image properties: features due to differences in spatial relationships,” Fiziol. Zh. im. I. M. Sechenova, in press.
R. I. Kruglikov, “The neurochemical mechanisms of memory,” in: Mechanisms of Memory [in Russian], Nauka, Leningrad (1987).
L. A. Firsov, I. P. Lapin, and L. A. Moiseeva, “The effects of phenamine and amizil on the interaction between delayed reactions and conditioned-reflex differentiation in rhesus macaques and capuchin monkeys,” Zh. Vyssh. Nerv. Deyat.,32, No. 4, 744–746 (1982).
K. B. Shapovalova, “Afferent and efferent mechanisms of increases in the cholinergic activity of the neostriatum,” Fiziol. Zh. im. I. M. Sechenova,80, No. 1, 47–59 (1994).
C. L. Colby, J. R. Duhamel, and M. E. Goldberg, “The analysis of visual space by the lateral intraparietal area of the monkey: the role of extraretinal signals,” Progr. Brain Res.,95, 307–316 (1993).
M. W. Decker and J. L. McGaugh, “The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory,” Synapse,7, 151–168 (1991).
M. E. Goldberg, C. L. Colby, and J. R. Duhamel, “Representation of visuomotor space in the parietal lobe of the monkey,” Cold Spring Harbor Symp. Quant. Biol.,55, 729–739 (1990).
J. Hyvarinen, The Parietal Cortex of Monkey and Man, Springer, Berlin (1982).
G. Lynch, J. Larson, U. Staubli, and R. Grander, “Variants of synaptic potentiation and different types of memory operations in hippocampus and related structures,” in: Memory: Organization and Locus of Change, L. R. Squire et al., Oxford University Press, Oxford (1991).
D. S. Olton, “Demental Animal models of the cognitive impairments following damage to the basal forebrain cholinergic systems,” Brain Res. Bull.,25, 499–502 (1990).
R. M. Ridley and H. F. Baker, “A critical evaluation of monkey models of amnesia and dementia,” Brain Res Rev.,16, 15–37 (1991).
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 83, No. 10, pp. 16–23, October, 1997.
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Dudkin, K.N., Chueva, I.V. Specific characteristics of cholinergic mechanisms of short-term memory in monkeys for different types of visual information: The effects of amizil. Neurosci Behav Physiol 29, 23–29 (1999). https://doi.org/10.1007/BF02461354
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DOI: https://doi.org/10.1007/BF02461354