, Volume 29, Issue 4–5, pp 195–198 | Cite as

Functional organization of calcium stores in polarized secretory cells and transcellular calcium transport

  • A. V. Tepikin
  • O. H. Petersen


In this short review, we will first discuss localized cytoplasmic calcium signals in pancreatic acinar cells. In the second part of the review, we will describe recently discovered polarized calcium efflux and calcium propagation through the lumen of the endoplasmic reticulum — ER (a phenomenon we have termed “calcium tunnelling”). Finally, we will present a hypothesis concerning the roles that these mechanisms could play in transcellular calcium flux.


Basal Part Secretory Granule Calcium Signal Apical Part Pancreatic Acinar Cell 
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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • A. V. Tepikin
    • 1
  • O. H. Petersen
    • 1
  1. 1.University of LiverpoolLiverpoolGreat Britain

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