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Basic mechanisms responsible for calcium signalling in neuronal cells

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Abstract

Calcium ions are the most universal intracellular messengers transmitting signals from the plasmalemma of excitable cells to the intracellular structures and triggering or modulating in this way most cellular functions. The molecular mechanisms responsible for injection of Ca ions into the cytoplasm during cellular activity and for producting transient elevations of their cytoplasmic free level (calcium “transient,” or “signals”) have been a subject of extensive investigation in numerous laboratories during last three decades. In a short review it is impossible to summarize the results obtained; two extensive publications on this subject have appeared already from our laboratory [1, 2]. Therefore, here the main attention will be paid to the most recent data from our laboratory concerning different aspects of the mechanisms forming calcium signals in neuronal cells.

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Kostyuk, P.G. Basic mechanisms responsible for calcium signalling in neuronal cells. Neurophysiology 29, 191–194 (1997). https://doi.org/10.1007/BF02461227

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