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Neuroscience and Behavioral Physiology

, Volume 29, Issue 4, pp 483–491 | Cite as

Short-term memory processes in delayed visual differentiation in rhesus macaques after bilateral removal of field 7 of the parietal cortex

  • K. N. Dudkin
  • I. V. Chueva
  • F. N. Makarov
  • I. V. Orlov
Article

Abstract

Monkeys (Macaca mulatta) with preliminary removal of field 7 of the lower parietal cortex and previously trained to differentiate images differing in shape, color, size, orientation, and spatial relationships were used to study the processes involved in short-term storage of different types of information required for a delayed (by 0–8 sec) visual differentiation task and the effects on these processes of the antioxidant Oxymetacil. Significant differences were found in comparison with intact animals. Removal of field 7 sharply worsened short-term storage processes during visual differentiation of different types of images, including those differing in terms of properties such as color, geometrical shape, and the spatial relationships between image elements. There were significant reductions in the level of correct responses for all delay periods with significant increases in the motor reaction time, indicating a sharp reduction in the duration of short-term information storage, which suggests that the monkeys' short-term memory mechanisms were disrupted. Oxymetacil had a correcting effect only in relation to stimuli differing in terms of color and shape, but had no effect at all on the short-term storage of spatial information. It is suggested that these data suggest that field 7 has at least two functions. These are, firstly, a role in processes underlying the evaluation, differentiation, and storage of spatial information depending on visual-vestibular interactions, and secondly, a role in the mechanisms underlying the attention system, which is disrupted by removal of field 7 and restored by treatment with the antioxidant when there is no need to differentiate spatial information, a process which depends on assessment of the body image and egocentric orientation based on visual-vestibular interactions.

Key Words

Rhesus macaque short-term memory visual differentiation parietal cortex field 7 extirpation the antioxidant Oxymetacil visual object properties 

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References

  1. 1.
    M. M. Bongard,Questions of Consciousness [in Russian], Nauka, Moscow (1967).Google Scholar
  2. 2.
    Yu. S. Borodkin and P. D. Shabanov,Neurochemical Mechanisms for Memory Trace Extraction [in Russian], Nauka, Leningrad (1986).Google Scholar
  3. 3.
    E. B. Burlakova, “The role of synaptic membrane lipids in information transmission and storage,” in:Studies of Memory [in Russian], Nauka, Leningrad (1999)0 pp. 146–153.Google Scholar
  4. 4.
    K. N. Dudkin,Visual Perception and Memory [in Russian], Nauka, Leningrad (1985).Google Scholar
  5. 5.
    K. N. Dudkin, V. K. Kruchinin, Yu. V. Skryminskii, and I. V. Chueva,Methods for Automated Studies of the Neuronal Mechanisms of Behavior [in Russian], Nauka, Leningrad (1989).Google Scholar
  6. 6.
    K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “The involvement of cholinergic structures of the prefrontal and lower temporal areas of the cortex in visual recognition processes in monkeys,”Ros. Fiziol. Zh. im. I. M. Sechenova,79, No. 2, 31–42 (1993).Google Scholar
  7. 7.
    K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “Synchronization processes in the mechanisms of short-term memory in monkeys: the involvement of cholinergic and glutamatergic cortical structures,”Ros. Fiziol. Zh. im. I. M. Sechenova,81, No. 8, 128–134 (1995).Google Scholar
  8. 8.
    K. N. Dudkin and I. V. Chueva, “The relationship between learning characteristics in rhesus macaques and the properties of visual objects,”Ros. Fiziol. Zh. im. I. M. Sechenova,81, No. 9, 25–34 (1995).Google Scholar
  9. 9.
    K. N. Dudkin, I. V. Chueva, and I. V. Orlov, “The relationship between short-term memory characteristics in monkeys and image properties: features responsible for the discrimination of spatial relationships,”Ros. Fiziol. Zh. im. I. M. Sechenova,83, No. 9, 51–59 (1997).Google Scholar
  10. 10.
    R. I. Kruglikov, “Neurochemical mechanisms of memory,” in:Mechanisms of Memory [in Russian], Nauka, Moscow (1987), pp. 78–87.Google Scholar
  11. 11.
    K. B. Shapovalova, “Afferent and efferent mechanisms increasing cholinergic activity in the neostriatum,”Ros. Fiziol. Zh. im. I. m. Sechenova,80, No. 1, 47–59 (1994).Google Scholar
  12. 12.
    S. O. Akbarian, O. J. Grusser, and W. O. Guldin, “Corticofugal connections between the cerebral cortex and brainstem vestibular nuclei in the macaque monkey,”J. Comp. Neurol.,339, 421–437 (1994).PubMedCrossRefGoogle Scholar
  13. 13.
    P. Bailey and C. von Bonin,The Neocortex of Macaca mulatta, Urbana (1947).Google Scholar
  14. 14.
    C. L. Colby and C. von Bonin, “The analysis of visual space by the lateral intraparietal area of the monkey: the role of extraretinal signals,”Progr. Brain Res.,95, 307–316 (1993).CrossRefGoogle Scholar
  15. 15.
    M. W. Decker and J. L. McGaugh, “The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory,”Synapse,7, 151–168 (1991).PubMedCrossRefGoogle Scholar
  16. 16.
    K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “An antioxidant-induced improvement in the cognitive characteristics of monkeys: neurophysiological correlates in the visual cortex,”Neurosci. Behav. Physiol.,24, No. 3, 289–296 (1994).PubMedCrossRefGoogle Scholar
  17. 17.
    M. E. Goldberg, C. L. Colby, and J. R. Duhamel, “Representation of visuomotor space in the parietal lobe of the monkey,”Cold Spring Harbor Symp. Quant. Biol.,55, 729–739 (1990).PubMedGoogle Scholar
  18. 18.
    W. O. Guldin, S. Akbarian, and O. J. Grusser, “Cortico-cortical connections and cytoarchitectonics of the primate vestibular cortex. A study in squirrel monkeys (Saimiri sciureus),”J. Comp. Neurol.,326, 375–401 (1992).PubMedCrossRefGoogle Scholar
  19. 19.
    J. Hyvarinen,The Parietal Cortex of Monkey and Man. Springer, Berlin (1982).Google Scholar
  20. 20.
    J. Lynch, “The functional organization of posterior parietal association cortex,”Behav. Brain. Sci.,3, 520–523 (1980).CrossRefGoogle Scholar
  21. 21.
    V. B. Mountcastle, J. C. Lynch, A. Georgopoulos, et al., “Posterior parietal association cortex of the monkey: command functions for operations within extrapersonal space,”J. Neurophysiol.,38, No. 4, 871–908 (1975).PubMedGoogle Scholar
  22. 22.
    D. S. Olton, “Dementia. Animal models of the cognitive impairments following damage to the basal forebrain cholinergic system,”Brain. Res. Bull.,25, 499–502 (1990).PubMedCrossRefGoogle Scholar
  23. 23.
    R. M. Ridley and H. F. A. Baker, “A critical evaluation of monkey models of amnesia and dementia,”Brain. Res. Rev.,16, 15–37 (1991).PubMedCrossRefGoogle Scholar
  24. 24.
    E. Vaadia, I. Haaiman, H. Bergman, Y. Prut, H. Slovin, and A. Aertsen, “Dynamics of neuronal interactions in monkey cortex in relation to behavioural events,”Nature,373, 515–518 (1995).PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • K. N. Dudkin
  • I. V. Chueva
  • F. N. Makarov
  • I. V. Orlov
    • 1
  1. 1.Cognitive Processes Modeling Group, CNS Morphology Laboratory, and Vestibular Function Laboratory, I. P. Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia

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