Neuroscience and Behavioral Physiology

, Volume 29, Issue 4, pp 359–363 | Cite as

Pre- and postsynaptic mechanisms of the involvement of amygdaloid complex serotonin in the reproduction of a conditioned passive avoidance response in rats

  • G. F. Molodtsova
  • R. Yu. Il'yuchenok
Article

Abstract

Serotonin metabolism and [3H]-serotonin radioligand receptor binding were studied in the amygdaloid complex of the rat brain at different stages of a conditioned passive avoidance response. Serotoninergic changes were specific for the process of reproduction of the conditioned response. The involvement of serotonin in the amygaloid complex during reproduction of memory traces consisted of a reduction in its postsynaptic receptor binding. The serotonin level in the amygaloid complex did not change, while changes in serotonin metabolism detected during reproduction of the conditioned avoidance response were associated with an increase in its deamination by monoamine oxidase and an increase in the active transport of 5-hydroxyindoleacetic acid from nerve terminals.

Keywords

Serotonin Conditioned Response Passive Avoidance Avoidance Response Memory Trace 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • G. F. Molodtsova
  • R. Yu. Il'yuchenok
    • 1
  1. 1.Cognitive Activity Physiology Laboratory, Memory Regulation Laboratory, Institute of Physiology, Siberian DivisionRussian Academy of Medical SciencesNovosibirsk

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