Bulletin of Mathematical Biology

, Volume 42, Issue 6, pp 861–870 | Cite as

Mathematical model of the activation of prothrombin by factor X a and factor V t

  • W. Liniger
  • G. Karreman
  • R. Rawala
  • R. Colman


A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases.


Thrombin Prothrombin Factor Versus Thrombin Formation Bovine Thrombin 
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Copyright information

© Society for Mathematical Biology 1980

Authors and Affiliations

  • W. Liniger
    • 1
  • G. Karreman
    • 2
    • 3
  • R. Rawala
    • 4
    • 5
  • R. Colman
    • 4
    • 5
  1. 1.Thomas J. Watson Research CenterYorktown HeightsU.S.A.
  2. 2.The Bockus Institute, Graduate HospitalUniversity of PennsylvaniaPhiladelphiaU.S.A.
  3. 3.Department of PhysiologyUniversity of PennsylvaniaPhiladelphiaU.S.A.
  4. 4.The Section of Hematology/OncologyTemple UniversityPhiladelphiaU.S.A.
  5. 5.Thrombosis CenterTemple UniversityPhiladelphiaU.S.A.

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