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Bulletin of Mathematical Biology

, Volume 42, Issue 6, pp 861–870 | Cite as

Mathematical model of the activation of prothrombin by factor X a and factor V t

  • W. Liniger
  • G. Karreman
  • R. Rawala
  • R. Colman
Article
  • 35 Downloads

Abstract

A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases.

Keywords

Thrombin Prothrombin Factor Versus Thrombin Formation Bovine Thrombin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Society for Mathematical Biology 1980

Authors and Affiliations

  • W. Liniger
    • 1
  • G. Karreman
    • 2
    • 3
  • R. Rawala
    • 4
    • 5
  • R. Colman
    • 4
    • 5
  1. 1.Thomas J. Watson Research CenterYorktown HeightsU.S.A.
  2. 2.The Bockus Institute, Graduate HospitalUniversity of PennsylvaniaPhiladelphiaU.S.A.
  3. 3.Department of PhysiologyUniversity of PennsylvaniaPhiladelphiaU.S.A.
  4. 4.The Section of Hematology/OncologyTemple UniversityPhiladelphiaU.S.A.
  5. 5.Thrombosis CenterTemple UniversityPhiladelphiaU.S.A.

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