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Mycoscience

, Volume 40, Issue 6, pp 525–529 | Cite as

Discovery of dicephalosterol, a new testosterone 5α-reductase inhibitor, and some new mycological aspects of its producer,Dicephalospora rufocornea (sclerotiniaceae, discomycetes)

  • Tsuyoshi Hosoya
  • Kiyoshi Hamano
  • Michihiro Sugano
  • Yoko Ogura
  • Emiko Hatano
  • Takakazu Hamada
Original Papers

Abstract

Dicephalosterol, a new testosterone 5α-reductase inhibitor, was found from isolates ofDicephalospora rufocornea, a sclerotiniaceous discomycete widely distributed, but not previously cultured. Under SEM observation, the polar appendage of the ascospores inD. rufocornea was found to be more solid than was hitherto reported. Dicephalosterol was produced by submerged fermentation for 7 d. This new analogue of testosterone showed an IC50 of 5.7 μg/ml for rat prostatic 5α-reductase, but no antimicrobial activity against bacteria or fungi.

Keywords

Testosterone Oily Substance Oatmeal Agar Microbial Resource Slant Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Mycological Society of Japan 1999

Authors and Affiliations

  • Tsuyoshi Hosoya
    • 1
  • Kiyoshi Hamano
    • 2
  • Michihiro Sugano
    • 2
  • Yoko Ogura
    • 3
  • Emiko Hatano
    • 4
  • Takakazu Hamada
    • 4
  1. 1.Tsukuba Research LaboratoriesSankyo Co. Ltd.Tsukuba, IbarakiJapan
  2. 2.Biomedical Research LaboratoriesSankyo Co. LtdTokyoJapan
  3. 3.Medical Information Department 1Sankyo Co. LtdTokyoJapan
  4. 4.Pharmacology and Molecular Biology Research LaboratoriesSankyo Co. Ltd.TokyoJapan

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