Abstract
A correlation matrix analysis is applied to the base sequence of MS2 and ϕX174 in comparison with sets of simulated sequences with different degrees of constaint Significant differences between a codified sequence, and a statistical one in terms of the “correlation matrix” for sets of different length cannot be found.
This result is analysed in terms of nucleotide sequences with different levels of informational content.
Similar content being viewed by others
Literature
Bennet, W. R. Jr. 1977. “How Artificial is Intelligence?”Am Scient.,65, 694–702.
Chaitin, G. J. 1975. “Randomness and Mathematical Proof”Scient. Am.,232, 47–52.
De Wachter, R., J. Merregaert, A. Vandenberghe, R. Contreras and W. Fiers. 1971. “Studies on the Bacteriophage MS2: the Untranslated 5′ Terminal Nucleotide Sequence Preceding the First Cistron.”Eur. J. Biochem.,22, 400–414.
Fiers, W., R. Contreras, F. Duerinck, G. Haegeman, J. Merregaert, W. Min Jou, A. Raeymakers, G. Volckaert, M. Yesebaert, J. Van Derkerckhove, F. Nolf and M. Van Montagu. 1975. “A Protein Gene of Bacteriophage MS2”.Nature,256, 273–278.
—, R. Contreras, F. Duerinck, G. Haegeman, D. Iserentant, J. Merregaert, W. Min Jou, F. Molemans, A. Rayemaekers, A. Van den Berghe, G. Volckaert and M. Ysebaert. 1976. “Complete Nucleotide Sequence of Bacteriophage MS2 RNA: Primary and Secondary Structure of the Replicase Gene.”Nature,260, 500–507.
Figueroa, R., A. Sepulveda, M. A. Soto and J. Toha. 1978. “Informational Analysis of MS2 and ϕX174 Virus Genomes.”J. Theor. Biol.,74, 203–207.
Kolmogorov, A. V. 1956.Foundations of Probability Theory. New York: Chelsea.
Kovàcs, A. L., E. Antonini, M. Brunori, G. M. Giacometti and L. Tentori. 1977. “Myoglobin from Aplysia: Some General Properties and a Proposal for the Three-Dimensional Structure.” InMyoglobin, Ed. A. G. Schneck and C. Vandecasserie, pp 52–74. Brussels: University of Brussels Press.
Sanger, F., G. M. Air, B. G. Barrell, N. L. Brown, A. R. Coulson, J. C. Fiddes, C. A. Hutchison III, P. M. Slocombe, and M. Smith. 1977. “Nucleotide Sequence of Bacteriophage ϕX174 DNA.”Nature 265, 687–695.
Shannon, E. C. and W. Weaver. 1949.The Mathematical Theory of Communication. Urbana, Ill: University of Illinois Press.
Tze-Fei Wong, J. 1975. “A Co-Evolution Theory of the Genetic Code.”Proc. Natn. Acad. Sci. U.S.A.,72, 1909–1912.
—. 1976. “The Evolution of a Universal Code.”Proc. Natn. Acad. Sci. U.S.A.,73, 2336–2340.
Vandenberghe, A., W. Min Jou and W. Fiers. 1975. “3 Terminal Nucleotide Sequence (n=361) of Bacteriophage MS2 RNA.”Proc. Natn. Acad. Sci. U.S.A.,72, 2559–2562.
Yockey, H. P. 1977. “A Calculation of the Probability of Spontaneous Biogenesis by Information Theory.”J. Theor. Biol.,67, 377–398.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kovacs, A.L., Pacitti, C., Conti, F. et al. A topological study of the base sequences of MS2 and ϕX174 genoma. Bltn Mathcal Biology 43, 81–88 (1981). https://doi.org/10.1007/BF02460941
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02460941