Abstract
The goal of this work is an examination of capillary exchange models as mathematical operators. The concentration function relations for the Krogh cylinder of a single capillary, basic to many organ models, are studied via the theory of operators on the Lebesgue normed spacesL p[0,∞], (1<-p<-∞). A discussion is included of theL p -normsvis-à-vis the coefficient of variation currently used in finding capillary parameters and evaluating parameter searches. The capillary model determines two operators on the space of locally integrable functions: O K (relating extravascular concentration to intravascular) and K a, k (relating intravascular concentration to input), wherek is the ratio of permeabilitysurface area (PS) to extravascular volume, and α is the ratio of PS to flow. These operators are shown to induce contractive (‖O K ‖ p <-1, ‖K a, k ‖ p <-1), isotone, linear operators onL p . The uniform convergence relation
(as operators onL p) is derived, whereP n (a) is the Poisson probabilitye −a a n/n!. For the important special cases ofp=∞, 1, 2 the norms are found (‖Ok‖=‖Ka,k‖p=1). Consideration is also given to the norms and operators when the functions involved are limited to a finite interval of time.
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This work supported in part by PHS Grant Nos HL-19153 (SCOR and Pulmonary Vascular Disease) and HL-19370.
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Bateman, J.M., Harris, T.R. Capillary operators. Bltn Mathcal Biology 46, 247–268 (1984). https://doi.org/10.1007/BF02460073
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DOI: https://doi.org/10.1007/BF02460073