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A quantitative description of membrane current and its application to conduction and excitation in nerve

Abstract

This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre (Hodgkinet al., 1952,J. Physiol. 116, 424–448; Hodgkin and Huxley, 1952,J. Physiol. 116, 449–566). Its general object is to discuss the results of the preceding papers (Section 1), to put them into mathematical form (Section 2) and to show that they will account for conduction and excitation in quantitative terms (Sections 3–6).

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Reprinted from theJournal of Physiology, Vol. 117, pp. 500–544 (1952) with the permission of the Physiological Society.

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Hodgkin, A.L., Huxley, A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. Bltn Mathcal Biology 52, 25–71 (1990). https://doi.org/10.1007/BF02459568

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Keywords

  • Membrane Potential
  • Positive Phase
  • Voltage Clamp
  • Membrane Current
  • Giant Axon