Transplant International

, Volume 2, Issue 2, pp 61–67 | Cite as

Organ transplantation in Japan — present status and problems

Invited Article


Kidney transplantation was first performed in Japan in 1956. Liver, heart, and pancreas transplantation began in 1964, 1968, and 1984, respectively. From 1964 until the end of 1987, 5328 kidney transplantations were performed in 122 facilities. A total of 75.7% of the grafts came from living related donors and 24.3% from cadavers. Although there were 80553 patients on dialysis at the end of 1987, only 572 renal transplants were performed that year. No liver or heart transplantations have been performed since 1968. In this review, data from the Japanese National Registry on Dialysis and Transplantation are presented. In addition, the social problems and public attitude towards brain death legislation and organ transplantation are discussed.

Key words

Kidney transplantation, in Japan Brain death, in Japan Transplantation, in Japan 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Collier DSJ, Calne R, Thiru S, Friend PJ, Lim S, White DJG, Kohno H, Levickis J (1987) FK-506 in experimental renal allografts. Transplant Proc 19:3975–3977PubMedGoogle Scholar
  2. 2.
    Dickneite G, Schorlemmer HU, Walter P, Sedlacek HH (1986) Graft survival in experimental transplantation could be prolonged by the action of the antitumoral drug. Transplant Proc 18:1295–1296Google Scholar
  3. 3.
    Inou T, Kusaba R, Takahashi I, Sugimoto H, Kuzahara K, Yamada Y, Yamauchi J, Otsubo O (1981) Clinical trial of bredinin in renal transplantation. Transplant Proc 13:315–318PubMedGoogle Scholar
  4. 4.
    Japan Society for Transplantation (1988) Kidney transplantation registry (1987) Jpn J Transplant 23:315–333Google Scholar
  5. 5.
    Kincaid-Smith P (1969) Modification of the vascular lesions of rejection in cadaveric renal allografts by dipyridamole and anticoagulants. Lancet II:920–922CrossRefGoogle Scholar
  6. 6.
    Kino T, Hatanaka H, Miyata S, Inamura N, Nishiyama M, Yajima T, Goto T, Okuhara M, Kohsaka M, Aoki H, Ochiai T (1987) FK-506, a novel immunosuppressant isolated from aStreptomyces. II. Immunosuppressive effect of FK-506 in vitro. J Antibiot 40:1256–1265PubMedGoogle Scholar
  7. 7.
    Ochiai T, Nakajima K, Nagata N, Suzuki T, Asano T, Uematsu T, Goto T, Hori S, Kenmochi T, Nakagoori T, Isono K (1987) Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc 19:1284–1286PubMedGoogle Scholar
  8. 8.
    Odaka M (1989) Present status of dialysis therapy in Japan (1988) J Jpn Soc Dial Ther 22:1–39Google Scholar
  9. 9.
    Sakaguchi K, Tsujino M, Yoshizawa M, Mizuno K, Hayano K (1975) Action of bredinin on mammalian cells. Cancer Res 35:1643–1648PubMedGoogle Scholar
  10. 10.
    Suzuki S, Kanashiro M, Watanabe H, Amemiya H (1988) The therapeutic effect of 15-deoxyspergualin on acute graft rejection detected by P nuclear magnetic resonance spectrography, and its effect on rat heart transplantation. Transplantation 46: 669–672PubMedGoogle Scholar
  11. 11.
    Teraoka S, Oba S, Takahashi K, Yagisawa T, Yamaguchi Y, Sanaka T, Tanabe K, Kawai T, Fuchinoue S, Honda H, Yasuo M, Hayasaka Y, Toma H, Agishi T, Ota K (1987) Therapeutic effect of antiplatelet agents on obstructive vascular lesions after kidney transplantation with cyclosporine. Transplant Proc 19:77–81PubMedGoogle Scholar
  12. 12.
    Todo S, Ueda Y, Demetris JA, Imventarza O, Nalesnik M, Venkataramanan R, Makowka L, Starzl TE (1988) Immuno-suppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction. Surgery 104:239–249PubMedGoogle Scholar
  13. 13.
    Uchida H, Yokota K, Akiyama N, Masaki Y, Aso K, Okubo M, Okudaira M, Kato M, Kashiwagi N (1979) Effectiveness of a new drug, bredinin, on canine kidney allotransplant survival. Transplant Proc 11:865–870PubMedGoogle Scholar
  14. 14.
    Voss BL, Hamilton KK, Samara ENS, McKee PA (1988) Cyclosporine suppression of endothelial prostacyclin generation. Transplantation 45:793–796PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • K. Ota
    • 1
  1. 1.Kidney CenterTokyo Women's Medical CollegeTokyoJapan

Personalised recommendations