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Some proposals in cardiac muscle mechanics and energetics

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Abstract

Based on A. V. Hill's three-component model, mechanical properties of the contractile element (CE), such as velocity and tension, were determined as muscle shortening and loads in quick-release or afterloaded isotonic contraction. The method is applicable for studying cardiac mechanics, to obtain force-velocity data of the same CE length at varous afterloads.

Analysis of the energetics of cardiac muscle was based on simulation studies of cardiac mechanics (Wong 1971, 1972). By proper derivation, the conventional contractile element work (CEW) was found to be a minor energy determinant. The tension-time integral and tension-independent heat (Ricchiuti and Gibbs, 1965) represent energy utilization for activation and maintenance of tension, the primary energy determinant.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

    Alan Y. K. Wong Ph.D.

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  1. Alan Y. K. Wong Ph.D.
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Wong, A.Y.K. Some proposals in cardiac muscle mechanics and energetics. Bltn Mathcal Biology 35, 375–399 (1973). https://doi.org/10.1007/BF02458344

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