Bulletin of Mathematical Biology

, Volume 56, Issue 1, pp 147–160 | Cite as

Probability of mast cells to mediate anaphylaxis in skeletal muscle

  • Gabriela Sánchez-Mejorada
  • Horacio Merchant-Larios
  • Francisco Alonso-deFlorida
  • Luis B. Morales
Article
  • 35 Downloads

Abstract

Are there enough mast cells in denervated skeletal muscle to account for autopharmacological mediation of the antigen potentials (APs) elicited by microtaps? Through rough qualitative estimations, some authors have suggested a positive answer to this question. However, in view of measurements performed in this investigation of both the density of mast cells and the diffusion coefficient of antigens, the probability of such mediated effects was found to be relatively low:P=0.016 for egg albumin andP=0.004 for ferritin. Therefore, most APs induced by microtaps should be attributed to the direct effect of antigen over the sensitized muscle fibers. Yet, both the density of mast cells found in this work and the known amount of histamine they are capable of releasing when challenged with antigen, support the hypothesis regarding the involvement of these cells when antigen is massively superfused so as to induce Schultz-Dale reactions in muscle strips. Under this circumstance, the direct and mediated mechanisms may coexist.

Keywords

Mast Cell Histamine Ferritin Muscle Strip Ferritin Concentration 

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Copyright information

© Society for Mathematical Biology 1993

Authors and Affiliations

  • Gabriela Sánchez-Mejorada
    • 1
  • Horacio Merchant-Larios
    • 1
  • Francisco Alonso-deFlorida
    • 1
  • Luis B. Morales
    • 2
  1. 1.Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoMéxico CityMéxico
  2. 2.FCFM Universidad de GuadalajaraGuadalajaraMéxico

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