Skip to main content
SpringerLink
Log in

Benzamide and its derivatives are active against botulinal intoxication

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A high antibotulinal activity of benzamide injected for prevention and of 3-N-butyrylamino-benzamide injected for treatment was observed in mice with intoxication caused by type A botulin toxin. 3-aminobenzamide and 3-N-butyrylaminobenzamide did not inhibit botulinal toxinin vitro.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. L. Belen'kii, in:Elements of Quantitative Assessment of Pharmacologic Effect [in Russian], Riga (1959), p. 40.

  2. V. G. Vladimirov, I. I. Krasil'nikov, Yu. E. Belyaev,et al., Radiobiologiya,32, No. 2, 261–265 (1992).

    CAS  Google Scholar 

  3. S. D. Zaugol'nikov, A. O. Loit, and A. M. Ivanitskii, in:General Problems of Industrial Toxicology [in Russian], Moscow (1967), p. 46.

  4. N. P. Chesnokova and G. Yu. Kulyash,Vopr. Med. Khimii, No. 1, 65–68 (1985).

    Google Scholar 

  5. G. E. Lewis, in:Biomedical Aspects of Botulism, New York-London-Paris (1981), pp. 261–270.

  6. J. Molgo, H. Lundh, and S. Thesleff,Eur. J. Pharmacol.,61, 25–34 (1980).

    Article  PubMed  CAS  Google Scholar 

  7. Y. Ohashi, T. Kamiya, and M. Fujiwara,Biochem. Biophys. Res. Commun.,142, No. 3, 1032–1038 (1987).

    Article  PubMed  CAS  Google Scholar 

  8. L. Peizhoneg, L. Jing, M. Wuyang,et al., Zhongcaoyao,13, No. 6, 28–30 (1982).

    Google Scholar 

  9. M. Puggliari and M. Cherington,JAMA,240, 2276 (1978).

    Article  Google Scholar 

  10. L. L. Simpson,Pharmacol. Rev.,33, 155–188 (1981).

    PubMed  CAS  Google Scholar 

  11. J. L. Sims, G. W. Sikorski, D. M. Catino,et al., Biochemistry,21, No. 8, 1813–1821 (1982).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clostridiosis, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

    G. A. Ugryumova, I. I. Krasil'nikov, O. F. Alferova, I. D. Vinogradova & Yu. V. Vertiev

  2. Institute of Military Medicine, Ministry of Defense of Russia, St. Petersburg

    G. A. Ugryumova, I. I. Krasil'nikov, O. F. Alferova, I. D. Vinogradova & Yu. V. Vertiev

Authors
  1. G. A. Ugryumova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. I. Krasil'nikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. F. Alferova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. D. Vinogradova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu. V. Vertiev
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 684–686, June, 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ugryumova, G.A., Krasil'nikov, I.I., Alferova, O.F. et al. Benzamide and its derivatives are active against botulinal intoxication. Bull Exp Biol Med 123, 593–595 (1997). https://doi.org/10.1007/BF02458088

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02458088

Key Words

Search

Navigation