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Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 6, pp 590–593 | Cite as

Cytokine therapy of experimental purulent wounds

  • L. V. Koval'chuk
  • L. V. Gankovskaya
  • A. P. Chadaev
  • Kh. A. Alikhanov
  • A. A. Dreval'
  • Ch. E. Manzaev
Microbiology and Immunology

Abstract

The effect of naturally occurring cytokine complex on aseptic and purulent wounds is examined in guinea pigs. Healing of aseptic wounds treated with the complex is 1.4 times faster than in the control: the rate of wound contraction reaches the maximum after 5–6 daysvs. 10–11 days in the control. Healing of these wounds occurs without pronounced inflammatory processes. Healing, epithelization, and wound cleansing are significantly faster in cytokine treated wounds than in the control. Histological analysis reveals formation of delicate cicatrices in cytokine-treated wounds, while rough cicatrices are observed in the control.

Key Words

cytokines purulent wounds guinea pigs 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • L. V. Koval'chuk
    • 1
  • L. V. Gankovskaya
    • 1
  • A. P. Chadaev
    • 1
  • Kh. A. Alikhanov
    • 1
  • A. A. Dreval'
    • 1
  • Ch. E. Manzaev
    • 1
  1. 1.Department of Immunology, Department of General SurgeryRussian State Medical UniversityMoscow

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