Abstract
The effects of the antiarrhythmic preparations lidocaine, flecainide, and rhlocaine on sodium concentration in cardiomyocyte cytoplasm are studied using the Na-sensitive fluorescent probe SBFI. The Na-blocking effect of lidocaine and rihlocaine depends on the frequency of electrical stimulation of cardiomyocytes (0.2–1.0 Hz). The data suggest the possibility ofin vitro testing of novel antiarrhythmic drugs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
P. A. Galenko-Yaroshevskii, A. I. Khankoeva, and A. S. Dukhanin,Byull. Eksp. Biol. Med.,122, No. 7, 45–47 (1996).
H. Hayashi, H. Satoh, N. Noda, H. Terada,et al., Am. J. Physiol.,266, No. 2, Pt. 1, C416-C422 (1994).
H. Ikenouchi, L. Zhao, and W H. Barry,,267, No. 2, Pt. 2, pp. H419-H430 (.
H. P. Rang, M. M. Dale, J. M. Ritter,Pharmacology, 286–291 (1995).
L. Ransnas, T. Hjalmarson, E. Sabler, and B. Jacobson,Pharmacol. Toxicol.,61, 107–110 (1987).
J. N. Ruskin,N. Engl. J. Med.,321, 386–388 (1989).
M. T. Slawsky and N. A. Castle,J. Pharmacol. Exp. Ther.,269, No. 1, 66–74 (1994).
V. Williams, in:Antiarrhythmic Drugs. Handbook of Experimental Pharmacology, Vol. 89, Berlin (1989).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6 pp. 666–668, June, 1997
Rights and permissions
About this article
Cite this article
Khankoeva, A.I., Dukhanin, A.S. & Galenko-Yaroshevskii, P.A. Comparative study of Na-blocking properties of antiarrhythmic drugs on isolated rat cardiomyocytes. Bull Exp Biol Med 123, 579–581 (1997). https://doi.org/10.1007/BF02458083
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02458083