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Energizing and antihypoxic effects of energostim

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is demonstrated that energostim, an aqueous mixture of NAD+, cytochromec, and inosine possesses pronounced antihypoxic activity. Energostim increases by 26-fold the survival rate of rats with low resistance to hypoxia under conditions of hypobaric hypoxia. Administration of energostim before the “rise” in a pressure chamber prevents a decrease in the brain content of ATP in rats with high resistance to hypoxia under the conditions of maximum hypoxia and increases it in rats with low resistance to hypoxia. Energostim has no effect on the survival rate of high-resistant rats in acute hypobaric hypoxia and on the brain content of macroergic substances in low- and high-resistant rats when agony is not developed on “the critical height” and there is no deficiency of macroergic substances.

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Authors and Affiliations

  1. Laboratory of Bioenergetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    L. D. Luk'yanova, A. M. Dudchenko, V. E. Romanova & E. L. Germanova

  2. Republican Research Institute, Center of Medical Biophysics, Ministry of Health, Republic Georgia, Tbilisi

    G. V. Sukoyan & N. V. Karsanov

Authors
  1. L. D. Luk'yanova
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  2. A. M. Dudchenko
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  3. V. E. Romanova
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  4. E. L. Germanova
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  5. G. V. Sukoyan
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  6. N. V. Karsanov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 659–662, June, 1997

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Luk'yanova, L.D., Dudchenko, A.M., Romanova, V.E. et al. Energizing and antihypoxic effects of energostim. Bull Exp Biol Med 123, 574–576 (1997). https://doi.org/10.1007/BF02458081

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  • DOI: https://doi.org/10.1007/BF02458081

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