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Central κ1 receptors and mechanisms of arrhythmogenesisreceptors and mechanisms of arrhythmogenesis

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Agonists of κ1-opiate receptors injected in brain ventricle potentiate arrhythmogenic effect of adrenaline. Antagonist of κ1-opiate receptors norbinaltorphimine or ganglioblocker hexamethonium completely abolish proarrythmic effects of κ1-agonists. Norbinaltorphimine possesses intrinsic antiarrhythmic activity.

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Authors and Affiliations

  1. Department of Experimental Cardiology, Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

    D. S. Ugdyzhekova, L. N. Maslov & Yu. B. Lishmanov

Authors
  1. D. S. Ugdyzhekova
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  2. L. N. Maslov
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  3. Yu. B. Lishmanov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 656–658, June, 1997

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Ugdyzhekova, D.S., Maslov, L.N. & Lishmanov, Y.B. Central κ1 receptors and mechanisms of arrhythmogenesisreceptors and mechanisms of arrhythmogenesis. Bull Exp Biol Med 123, 571–573 (1997). https://doi.org/10.1007/BF02458080

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  • DOI: https://doi.org/10.1007/BF02458080

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