Abstract
After administration of 5-fluorouracil in a high dose (114 mg/kg), the proliferation of committed precursors of erythro- and granulomonocytopoiesis is controlled by sympatheticoadrenal system. On the one hand, catecholamines facilitate, predominantly via β-structures, the migration of Thy-1+-cells that stimulate hemopoietic precursors for the S-phase of cell cycle. On the other hand, sympatheticoadrenal transmitters potentiate via β- and α-adrenoreceptors the suppressor activity of the cytostatic on the growth and maturation of erythropoietic and, to a lesser extent, granulocytopoietic precursors. These factors may contribute to the process of long restoration of the granulocyte and, to a higher extent, erythrocyte stem cells in the bone marrow after a high dose of 5-fluorouracil.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. P. Balitskii and Yu. P. Shmal'ko,Stress and Metastasizing of Malignant Tumors [in Russian], Kiev (1987).
V. E. Gol'dberg, A. M. Dygai, and V. V. Novitskii,Lung Cancer and Blood System [in Russian], Tomsk (1992).
E. D. Goldberg, A. M. Dygai, and V. P. Shakhov,Tissue Culturing in Hematology [in Russian], Tomsk (1992).
E. D. Gol'dberg, I. A. Khlusov, A. M. Dygai, and V. I. Agafonov,Byull. Eksp. Biol. Med.,116, No. 11, 457–460 (1993).
P. D. Gorizontov, O. I. Belousova, and M. I. Fedotova,Stress and Blood System [in Russian], Moscow (1983).
A. M. Dygai, I. A. Khlusov, S. G. Aksinenko,et al., Byull. Eksp. Biol. Med.,119, No. 2, 135–140 (1995).
V. D. Dyshlovoi, V. S. Kachura, and A. S. Panchuk,Cytologiya Genetika, No. 3, 201–204 (1976).
G. I. Kozinets and E. D. Gol'dberg (Eds.),Kinetic Aspects of Hemopoiesis [in Russian], Tomsk (1982).
E. V. Melik-Gaikazyan,Probl. Gematol., No. 8, 48–50 (1980).
N. A. Fedorov,Biological and Clinical Significance of Cyclic Nucleotides [in Russian], Moscow (1979).
I. A. Khlusov, A. M. Dygai, S. G. Aksinenko, and E. D. Gol'dberg,Byull. Eksp. Biol. Med.,115, No. 4, 372–375 (1993).
D. A. Shmarov and V. N. Pershin,Vestn. Ross. Akad. Med. Nauk, No. 4, 8–12 (1993).
A. A. Yarilin, I. V. Miroshnichenko, and V. P. Shichkin,Itogi Nauki Tekhniki, Ser. Immunologiya [in Russian], Moscow (1990).
A. P. Yastrebov, B. G. Yushkov, V. N. Bol'shakov,Regulation of Hemopoiesis Under the Influence of Extreme Factors [in Russian], Sverdlovsk (1988).
E. D. Goldberg and A. M. Dygai,Sov. Med. Rev. C. Hematology,4, 11–67 (1992).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 638–641, June, 1997
Rights and permissions
About this article
Cite this article
Khlusov, I.A., Dygai, A.M. & Gol'dberg, E.D. Dependence of the proliferation of hemopoietic adrenergic precursors under the influence of cytostatics. Bull Exp Biol Med 123, 555–558 (1997). https://doi.org/10.1007/BF02458075
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02458075