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Effect of lidocaine on cholera vibrio-induced changes in the jejunum, renal medulla, and lungs of suckling rabbits

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Lidocaine injected into suckling rabbits infected with a virulent strain ofVibrio cholerae abolishes the development of hydropic and ballooning degeneration the jejunal enterocytes. Secretory granules and lipid inclusions accumulate in jejunal enterochromaffin cells and interstitial cells of renal medulla, respectively, and are not released into the vascular bed. In pulmonary tissue ultrastructural changes are mild, and capillary epithelium is undamaged, indicating that lidocaine stimulates pulmonary enzymes which inactivate biologically active substances implicated in the pathogenesis of cholera.

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Authors and Affiliations

  1. Laboratory of Pathomorphology and Pathophysiology, Antiplague Institute, Rostov-on-Don

    E. A. Bardakhch'yan, Yu. M. Lomov & N. G. Kharlanova

Authors
  1. E. A. Bardakhch'yan
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  2. Yu. M. Lomov
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  3. N. G. Kharlanova
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 632–637, June, 1997

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Bardakhch'yan, E.A., Lomov, Y.M. & Kharlanova, N.G. Effect of lidocaine on cholera vibrio-induced changes in the jejunum, renal medulla, and lungs of suckling rabbits. Bull Exp Biol Med 123, 550–554 (1997). https://doi.org/10.1007/BF02458074

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  • DOI: https://doi.org/10.1007/BF02458074

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