Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 6, pp 548–550 | Cite as

Adaptogen ADAPT modulates stress-induced HSP70 synthesis and improves organism's resistance to heat shock

  • P. A. Prodius
  • E. B. Manukhina
  • A. E. Bulanov
  • G. Wikman
  • I. Yu. Malyshev
General Pathology and Pathological Physiology

Abstract

The effect of the herbal adaptogen ADAPT on the basal and heat shock-induced synthesis of HSP70 and organism's resistance to heat shock is studied. It is shown that ADAPT decreases accumulation of these proteins in the myocardium and promotes their accumulation in the liver. ADAPT has no effect on arterial pressure but prevents its drop induced by heat shock and markedly increases the survival rate of experimental animals. These data agree with the hypothesis that the effect of ADAPT on the synthesis of HSP70 is an important component of its protective action.

Key Words

ADAPT adaptogens heat shock heat shock proteins survival rate 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • P. A. Prodius
    • 1
    • 2
  • E. B. Manukhina
    • 1
    • 2
  • A. E. Bulanov
    • 1
    • 2
  • G. Wikman
    • 1
    • 2
  • I. Yu. Malyshev
    • 1
    • 2
  1. 1.Institute of General Pathology and Pathological PhysiologyRussian Academy of Medical SciencesMoscow
  2. 2.Institute of PlantsGöteborgSweden

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