Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 6, pp 525–533 | Cite as

Common clinical manifestations of serotonin deficiency and intoxication syndrome

  • A. P. Simonenkov
  • V. D. Fedorov


Clinical manifestations of serotonin deficiency, its genesis, diagnostics, and treatment are described. the contribution of free hemoglobin and myoglobin to the genesis of absolute serotonin deficiency — disseminated intravascular coagulation (DIC) syndrome — is shown. Evidence is presented suggesting that chronic serotonin deficiency underlies aged-related and diabetic angiopathies. It is demonstrated that the serotonin deficiency syndrome has common clinical manifestations with the intoxication syndrome.

Key Words

serotonin serotonin-ferroprotein receptors serotonin deficiency syndrome smooth muscle insufficiency intoxication syndrome DIC syndrome 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. B. Gorpinich, V. D. Zatolokin, A. P. Simonenkov,et al., A Method of Modeling Antiperistalsis in Experiments (Decision to grant a patent for the invention of this method was taken February 13, 1996), [in Russian].Google Scholar
  2. 2.
    V. V. Men'shikov,Clinical Laboratory Methods of Investigation. A Handbook [in Russian], Moscow (1987).Google Scholar
  3. 3.
    V. V. Men'shikov, L. S. Bassalyk, and G. A. Shapiro,The Carcinoid syndrome [in Russian], Moscow (1972).Google Scholar
  4. 4.
    I. N. Pidevich,The Pharmacology of Serotonin-Reactive Structures [in Russian], Moscow (1977).Google Scholar
  5. 5.
    G. A. Ryabov,Syndromes of Critical States [in Russian], Moscow (1994).Google Scholar
  6. 6.
    D. S. Sarkisov,Essays on the History of General Pathology [in Russian], Moscow (1993).Google Scholar
  7. 7.
    P. V. Sergeev, P. A. Galenko-Yaroshevskii, and N. L. Shimanovskii,Essays on Biochemical Pharmacology [in Russian], Moscow (1996).Google Scholar
  8. 8.
    P. V. Sergeev and N. L. Shimanovskii,Receptors [in Russian], Moscow (1987).Google Scholar
  9. 9.
    A. P. Simonenkov, “Functional intestinal obstruction, disseminated intravascular coagulation, and a symptom-complex caused by poisoning with psychotropic drugs as clinical manifestations of serotonin deficiency,” Author's Synopsis of Doct. Med. Sci. Dissertation [in Russian], Moscow (1992).Google Scholar
  10. 10.
    A. P. Simonenkov and V. D. Fedorov,Byull. Eksp. Biol. Med.,123, No. 1, 103–110 (1997).CrossRefGoogle Scholar
  11. 11.
    A. P. Simonenkov, V. D. Fedorov, and A. A. Galkin,Byull. Eksp. Biol. Med.,121, No. 4, 467–469 (1996).Google Scholar
  12. 12.
    A. P. Simonenkov, V. D. Fedorov, A. V. Fedorov,et al., Vestn. Ross. Akad. Med. Nauk, No. 6, 11–15 (1994).PubMedGoogle Scholar
  13. 13.
    A. P. Simonenkov, V. D. Fedorov, A. V. Fedorov,et al., Vestn. Ross. Akad. Med. Nauk, No. 6, 27–30 (1995).PubMedGoogle Scholar
  14. 14.
    A. P. Simonenkov, V. D. Fedorov, A. V. Fedorov,et al., Vestn. Ross. Akad. Med. Nauk, No. 12, 45–51 (1995).PubMedGoogle Scholar
  15. 15.
    V. D. Fedorov,Treatment of Peritonitis [in Russian], Moscow (1974).Google Scholar
  16. 16.
    R. Blattner, H. Classen, H. Dehnert, and H. Doring,Experiments on Isolated Smooth Muscle preparations, Basel (1978).Google Scholar
  17. 17.
    F. Hucho,Neurochemistry. Fundamentals and Concepts, Weinheim (1986).Google Scholar
  18. 18.
    H. Ormsbee and J. Fondacaro,Proc. Soc. Exp. Biol. Med.,178, No. 3, 333–338 (1985).PubMedGoogle Scholar
  19. 19.
    I. H. Page,Serotonin, Chicago (1968).Google Scholar
  20. 20.
    M. M. Rapport, A. A. Green, and I. H. Page,J. Biol. Chem.,176, 1243 (1948).PubMedGoogle Scholar
  21. 21.
    G. Riecker,Shock, Berlin (1984).Google Scholar
  22. 22.
    P. M. Vanhoutte,Serotonin and the Cardiovascular System, New York (1985).Google Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • A. P. Simonenkov
    • 1
  • V. D. Fedorov
    • 1
  1. 1.Center for Investigation of the Role of Serotonin in the Body, A. V. Vishnevskii Institute of SurgeryRussian Academy of Medical SciencesMoscow

Personalised recommendations