Abstract
Based on the flow field solution of the three-porous-medium model for tumor microcirculation, the diffusion-convection equations are solved with various initial and boundary conditions using finite element method. The concentration profile of two therapeutic agents: immunoglobulin G (IgG) and its antigen-binding fragment (Fab) in blood, lymph and interstitial fluid are obtained for normal-tissue-surrounded tumor. The effect of tumor microvasculature, lymph function, drug injection mode, the molecular weight and binding kinetics of the drug on the distribution in tumors are also considered.
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Xiaoxiao, L., Wangyi, W., Gongbi, W. et al. Mass transport in solid tumors (II) —Drug delivery. Appl Math Mech 19, 1151–1160 (1998). https://doi.org/10.1007/BF02456636
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DOI: https://doi.org/10.1007/BF02456636