Applied Mathematics and Mechanics

, Volume 19, Issue 12, pp 1151–1160 | Cite as

Mass transport in solid tumors (II) —Drug delivery

  • Lei Xiaoxiao
  • Wu Wangyi
  • Wen Gongbi
  • Chen Jianguo
Article
  • 42 Downloads

Abstract

Based on the flow field solution of the three-porous-medium model for tumor microcirculation, the diffusion-convection equations are solved with various initial and boundary conditions using finite element method. The concentration profile of two therapeutic agents: immunoglobulin G (IgG) and its antigen-binding fragment (Fab) in blood, lymph and interstitial fluid are obtained for normal-tissue-surrounded tumor. The effect of tumor microvasculature, lymph function, drug injection mode, the molecular weight and binding kinetics of the drug on the distribution in tumors are also considered.

Key words

three-porous-medium model solid tumor drug delivery diffusion-convection equations 

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References

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Copyright information

© Editorial Committee of Applied Mathematics and Mechanics 1980

Authors and Affiliations

  • Lei Xiaoxiao
    • 1
  • Wu Wangyi
    • 1
  • Wen Gongbi
    • 1
  • Chen Jianguo
    • 1
  1. 1.Department of Mechanics and Engineering SciencePeking UniversityBeijingP. R. China

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