Mass transport in solid tumors (II) —Drug delivery
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Based on the flow field solution of the three-porous-medium model for tumor microcirculation, the diffusion-convection equations are solved with various initial and boundary conditions using finite element method. The concentration profile of two therapeutic agents: immunoglobulin G (IgG) and its antigen-binding fragment (Fab) in blood, lymph and interstitial fluid are obtained for normal-tissue-surrounded tumor. The effect of tumor microvasculature, lymph function, drug injection mode, the molecular weight and binding kinetics of the drug on the distribution in tumors are also considered.
Key wordsthree-porous-medium model solid tumor drug delivery diffusion-convection equations
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