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Molecular and Cellular Biochemistry

, Volume 110, Issue 2, pp 169–173 | Cite as

Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin

  • William B. Weglicki
  • Terry M. Phillips
  • Anthony M. Freedman
  • Marie M. Cassidy
  • Benjamin F. Dickens
Article

Summary

We have developed two rodent models of diet-induced magnesium-deficiency in which histologically defined cardiac lesions can be induced within two to three weeks. During the development of these lesions, the magnesium-deficient animals exhibit circulating cytokine levels which are indicative of a generalized inflammatory state. Dramatic elevations of the macrophage-derived cytokines, IL-1, IL-6, and TNF-α together with signigicantly elevated levels of the endothelial cell-derived cytokine, endothelin, were detected in the plasma of these animals. We believe that the pathophysiological effects caused by the action of these cytokines may play a role in the promotion of cardiovascular pathology associated with magnesium deficiency.

Key words

cardiomyopathy TNF-α IL-1 IL-6 free radical mechanisms 

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • William B. Weglicki
    • 1
    • 2
  • Terry M. Phillips
    • 1
    • 2
  • Anthony M. Freedman
    • 1
    • 2
  • Marie M. Cassidy
    • 1
    • 2
  • Benjamin F. Dickens
    • 1
    • 2
  1. 1.Department of MedicineThe George Washington University Medical CenterWashington DCUSA
  2. 2.Department of PhysiologyThe George Washington University Medical CenterWashington DCUSA

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