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Serum antioxidant enzyme activity in Parkinson's disease

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Summary

The activities of superoxide dismutase (SOD; EC 1.15.1.1) and glutathione peroxidase (GSHPx; EC 1.11.1.9.), the enzymes that metabolize the superoxide anion and hydrogen peroxide, respectively, were measured in serum from healthy subjects and patients with Parkinson's disease (PD). The activities of SOD and GSHPx in patients with PD were higher than those in normal healthy individuals. These results suggest that the increased activities of these enzymes could be due to oxidative stress in the initial stages of this disease.

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Authors and Affiliations

  1. Department of Pathology College of Medicine, University of Saskatchewan, S7N OXO, Saskatoon, Saskatchewan, Canada

    Jawahar Kalra, Ali H. Rajput, Subrahmanyam V. Mantha & Kailash Prasad

  2. Department of Medicine and Physiology, College of Medicine, University of Saskatchewan, S7N OXO, Saskatoon, Saskatchewan, Canada

    Jawahar Kalra, Ali H. Rajput, Subrahmanyam V. Mantha & Kailash Prasad

  3. Royal University Hospital, S7N OXO, Saskatoon, Saskatchewan, Canada

    Jawahar Kalra, Ali H. Rajput, Subrahmanyam V. Mantha & Kailash Prasad

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  1. Jawahar Kalra
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  2. Ali H. Rajput
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  3. Subrahmanyam V. Mantha
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  4. Kailash Prasad
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Kalra, J., Rajput, A.H., Mantha, S.V. et al. Serum antioxidant enzyme activity in Parkinson's disease. Mol Cell Biochem 110, 165–168 (1992). https://doi.org/10.1007/BF02454194

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  • DOI: https://doi.org/10.1007/BF02454194

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