Roux's archives of developmental biology

, Volume 198, Issue 2, pp 65–77 | Cite as

Pattern triplications following genetic ablation on the wing ofDrosophila

Effect of eliminating thepolyhomeotic gene
  • Pedro Santamaria
  • Janet Deatrick
  • Neel B. Randsholt


The effects ofpolyhomeotic (ph) mutants in imaginal cells have been studied in a clonal analysis. Clones of cells, homozygous forph, sort-out after a few divisions, probably as a consequence of modified cell affinities. The dorso-ventral margin of the wing has special characteristics that retard this phenomenon. The formation and exclusion of a clone of 8–16 cells affect the polarity of the wild-type neighbour cells and can provoke pattern triplications. The results suggest that a defect in intercellular communication prevents the wild-type cells from maintaining coordinated positional information. The cells react by regenerative growth, and reorganize into a new pattern. The pleiotropic phenotypes ofph mutants are explained according to a common hypothesis aboutph + function.

Key words

Cell communication Pattern formation Cell differentiation trans-regulatory genes Drosophila 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Pedro Santamaria
    • 1
    • 2
  • Janet Deatrick
    • 1
    • 2
  • Neel B. Randsholt
    • 1
    • 2
  1. 1.Centre de Génétique Moléculaire du C.N.R.S.Gif-sur-Yvette CedexFrance
  2. 2.Laboratoire propre du C.N.R.S.associe à l'Université Pierre et Marie CurieParis VIFrance

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