Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 5, pp 1112–1114 | Cite as

Culturing of interspecies hybridomas in immunologically tolerant animals

  • N. V. Kobets
  • E. V. Nagurskaya
  • A. K. Yazova
  • L. N. Fontalin
  • I. Yu. Chernyakhovskaya
Microbiology and Immunology
  • 23 Downloads

Abstract

A new method of culturing monoclonal antibody-producing rat—mouse hybridomas in mice tolerant to the transplantation antigens of rats is described.

Key Words

hybridoma xenotolerance monoclonal antibodies mouse α-fetoprotein 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • N. V. Kobets
    • 1
    • 2
  • E. V. Nagurskaya
    • 1
    • 2
  • A. K. Yazova
    • 1
    • 2
  • L. N. Fontalin
    • 1
    • 2
  • I. Yu. Chernyakhovskaya
    • 1
    • 2
  1. 1.Laboratory of Immunological Tolerance, N. F. Gamaleya Institute of Epidemiology and MicrobiologyRussian Academy of Medical SciencesMoscow
  2. 2.Laboratory of Immunochemistry, Oncology Research CenterRussian Academy of Medical SciencesMoscow

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