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Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 5, pp 1082–1084 | Cite as

p-Aminobenzoic acid as a stimulator of angiogenesis

  • S. I. Akberova
  • A. A. Sologub
  • O. G. Stroeva
General Pathology and Pathological Physiology
  • 18 Downloads

Abstract

p-Aminobenzoic acid (0.002 and 0.005% in a volume of 0.1 ml) stimulates angiogenesis in the yolk sac of chick embryos. It is more effective in a concentration of 0.005%, significantly increasing the length and branching of large vessels (by 27–33% and 35–43%, respectively) in comparison with the control (injection of 0.1 ml normal saline).

Key Words

p-aminobenzoic acid angiogenesis yolk sac chilck embryos 

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References

  1. 1.
    Objects of Developmental Biology [in Russian], Moscow (1975), pp. 470, 473.Google Scholar
  2. 2.
    I. A. Rapoport, in:Phenogenetic Analysis of Independent and Dependent Differentiation, Proceedings of the Institute of Cytology, Histology, and Embryology [in Russian], Vol. 2, Moscow (1948), Issue 1, pp. 51–52.Google Scholar
  3. 3.
    P. F. Rokitskii, in:Fundamentals of Variational Statistics for Biologists [in Russian], Minsk (1961), pp. 104–113.Google Scholar
  4. 4.
    A. A. Sologub, S. I. Akberova, and G. G. Ziangirova,Byull. Eksp. Biol. Med.,114, No. 12, 620–622 (1992).Google Scholar
  5. 5.
    A. A. Sologub, I. G. Panova, and O. G. Stroeva,Ontogenesis,25, No. 6, 54–59 (1994).Google Scholar
  6. 6.
    O. G. Stroeva, V. A. Poplinskaya, I. P. Khoroshilova-Maslova, and I. A. Rapoport,Dokl. Akad. Nauk SSSR,31, No. 2, 483–487 (1990).Google Scholar
  7. 7.
    I. A. Rapoport (Ed.),Chemical Mutagens and Para-Aminobenzoic Acid in Raising the Crop Yield [in Russian], Moscow (1989).Google Scholar
  8. 8.
    G. Alessandry, K. Raju, and P. M. Gullino,Cancer Res.,43, 1790–1797 (1983).Google Scholar
  9. 9.
    S. B. Goren, R. Eisenstein, and E. Choromokos,Am. J. Ophthalmol.,84, 305–309 (1977).PubMedGoogle Scholar
  10. 10.
    S. Taylor and I. Folkman,Nature,197, 307–312 (1982).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • S. I. Akberova
    • 1
    • 2
  • A. A. Sologub
    • 1
    • 2
  • O. G. Stroeva
    • 1
    • 2
  1. 1.N. K. Kol'tsoy Institute of Developmental BiologyRussian Academy of SciencesMoscow
  2. 2.N. N. Narimanov Azerbaijan Medical UniversityBaku

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