Bulletin of Experimental Biology and Medicine

, Volume 122, Issue 5, pp 1071–1073 | Cite as

Extremely low doses of oxytocin reduce pain sensitivity in men

  • Yu. V. Uryvaev
  • G. A. Petrov


The effect of extremely low doses of oxytocin (vapor) on the perception of pain (pricking of the finger) is studied on 48 healthy volunteers. Inhalation of oxytocin vapor from the standard solution in doses producing a sensation of smell lowers pain threshold by 56.5%. Inhalation of oxytocin vapor creating no sense of smell has a lower hypalgesic effect. The oxytocin-induced hypalgesia is consistent with reduction in the heart reactivity to pain.

Key Words

oxytocin hypalgesia pain 


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  1. 1.
    R. M. Baevskii, O. I. Kirillov, and S. Z. Kletskin,Mathematical Analysis of Changes in Cardiac Rhythms in Stress [in Russian], Moscow (1984).Google Scholar
  2. 2.
    Yu. V. Uryvaev, N. K. Golubeva, and A. M. Nechaev,Dokl. Akad. Nauk SSSR,290, No. 2, 501–504 (1986).PubMedGoogle Scholar
  3. 3.
    Yu. V. Uryvaev and Yu. P. Zverev,,317, No. 1, 242–245 (1991).PubMedGoogle Scholar
  4. 4.
    E. C. Huskisson,Lancet, No. 2 (7889), 1127–1131 (1974).PubMedCrossRefGoogle Scholar
  5. 5.
    G. M. Shepherd,Ann. N.Y. Acad. Sci.,510, 98–103 (1987).PubMedGoogle Scholar
  6. 6.
    K. Uvnas-Moberg, G. Bruzelius, P. Alster,et al., Acta Physiol. Scand.,144, No. 4, 487–488 (1992).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Yu. V. Uryvaev
    • 1
    • 2
  • G. A. Petrov
    • 1
    • 2
  1. 1.Department of Normal PhysiologyI. M. Sechenov Moscow Medical AcademyMoscowUSSR
  2. 2.Department of Normal PhysiologyTver' Medical AcademyMoscowUSSR

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