Abstract
The purpose of this paper is to present the genetic distribution at the HLA-A, B and C loci in the Galician population (Spain). A random sample of 264 unrelated individuals from the autochtonous population were tested. The gene frequencies observed at the three loci are within the respective variability ranges found in European populations. The linkage disequilibrium value, D, was calculated using the phenotype frequencies at the A-B, A-C and B-C loci; the most frequent haplotype combinations were A1-B8 and A2-B44, A2-Cw7 and A1-Cw7, and B7-Cw7 and B35-Cw4, respectively.
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References
Aluja M.P., Ercilla M.G. & Font A., 1989.HLA gene and haplotype frequencies in a Spanish East Pyrenean population. Humanbiol., 19: 129–135.
Arnaiz Villena A., Rodriguez de Cordoba S., Vela F., Pascual J.C., Cervero J. & Botello A., 1981.HLA antigens in a sample of the Spanish Population: common features among Spaniards, Basques and Sardinians. Hum. Genet., 58: 344–348.
Baur M.P., Neugebauer M., Deppe M., Sigmund M., Luton T., Mayr W.R. & Albert E.D., 1984.Population analysis on the basis of deduced haplotypes from random families. Histocompatibility testing: 333–341.
Calvet R., Pastor J.M., Fernandez R., Zubizarreta A. & Romero J.L., 1991.HLA phenotype and haplotype frequencies in the Cantabria (Middle North Spain) population. Hum. Hered., 41: 324–329.
Carvalho A.S., 1983.HLA-A, B and C markers in Portuguese Population. Tissue Antigens, 21: 39–44.
Degos L., 1985.La répartition anthropologique des gènes HLA et la dynamique des populations. In, Dausset & Pla: HLA. Complexe majeur d'histompatibilité de l'homme. Flammarion, Paris.
Garcia de Mesdevall M.D., Ercilla M.G., Arrieta A. & Vives J., 1982.Estudio genético del sistema HLA en la poblacion vasca. Sangre, 27(2): 182–189.
Llorente L. & Campillo F.L. 1979.Estudio del sistema HLA en la poblacion espanola. Sangre, 24(3) 271–276.
Martinez Labarga C., 1988.El sistema HLA en España. Bol. Soc. Esp. Antropol. Biol., 9: 5–20.
Mattiuz P.L., Ihde D., Piazza R., Ceppellini R. & Bodmer W.F., 1970.New approaches to the population genetic and segregation analysis of the HLA-system. In, Terasaki: Histocompatibility testing: 193–205. Munksgaard, Copenhagen.
Menozzi P., Piazza A. & Cavalli-Sforza L.L., 1978.Synthetic maps of human gene frequencies in Europeans. Science, 201: 786–792.
Olivetti E., Rendine S., Capello N., Curtoni E.S. & Piazza A., 1986.The HLA system in Italy. Hum. Hered., 36: 357–372.
Reen D.J. & O'Regan D., 1980.HLA antigen frequencies in an Irish Population. Tissue Antigens, 15: 369–372.
Renieri N., Stavropoulos C. & Lepage V., 1979.The distribution of HLA antigens and genes in the Greek population. Tissue Antigens. 13: 154–157.
Terasaki P.I., Bernoco D., Park, M.S., Ozturk G. & Iwaki Y., 1978.Microdroplet testing for HLA-A, B, C and D. Am.J.Clin.Path., 69: 103–120.
Thomsom G., 1983.The human histocompatibility system: anthropological considerations. Am. J. Phys. Anthropol., 62: 81–89.
Vives J., Ercilla G., Castillo R. & Rozman C., 1975.A study of the HLA system in the Spanish Population. In: KIssmeyer-Nielsen: Histocompatibility testing: 233–238, Munksgaard, Copenhagen.
Yasuda N. & Kimura M., 1968.A gene-counting method of maximum likelihood for estimating gene frequencies in ABO and ABO-like systems. Ann. Hum. Genet., 31: 409–420.
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Varela, T.A., Lodeiro, R. & Fariña, J. HLA gene and haplotype frequencies in Galicia (NW spain). Int. J. Anthropol. 8, 15–20 (1993). https://doi.org/10.1007/BF02447638
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DOI: https://doi.org/10.1007/BF02447638