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Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 3, pp 925–927 | Cite as

Adrenergic and cholinergic control on the heart in rat ontogenesis

  • F. G. Sitdikov
  • T. A. Anikina
  • R. I. Gil'mutdinova
Biophysics and Biochemistry
  • 19 Downloads

Abstract

The concentrations of acetylcholine and norepinephrine and acetylcholinesterase activity in the myocardium as well as chronotropic cardiac response to exogenous mediators administered in increasing doses were studied in experiments on growing rats. The results indicate that the chronotropic response to norepinephrine decreases with age despite of increased intracardial concentration of norephinephrine. Cholinergic influence and myocardial reactivity to acetylcholine increase with age.

Key Words

norepinephrine acetylcholine acetylcholinesterase sensitivity reactivity 

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References

  1. 1.
    R. A. Abzalov,Motion and the Developing Heart [in Russian], Moscow (1985).Google Scholar
  2. 2.
    T. A. Anikina,Functional State of Sympathoadrenal and Acetylcholine-Cholinesterase Systems in Rat Ontegenesis and during Physical Loading [in Russian], Abstracts of Ph.D. Thesis in Biology, Kazan' (1990).Google Scholar
  3. 3.
    I. A. Arshawski,Physiological Mechanisms and Principles of Individual Growth [in Russian], Moscow (1982).Google Scholar
  4. 4.
    G. E. Batrak and L. N. Kudrin,Drug Doses Applied in Animals [in Russian], Moscow (1979).Google Scholar
  5. 5.
    R. I. Gil'mutdinova,Effects of Exogenous Norepinephrine and Acetylcholine on the Heart in Rat Ontogenesis under Various Conditions of Locomotions [in Russian], Abstracts of Ph.D. Thesis in Biology, Kazan' (1991).Google Scholar
  6. 6.
    V. I. Makhin'ko and V. N. Nikitin, in:Molecular and Physiological Mechanisms of Aging [in Russian], 308–325, Kiev (1975).Google Scholar
  7. 7.
    F. G. Sitdikov,Mechanisms and Age Pecularities of Adaptation of the Heart to Simpathetic Influence [in Russian], Abstracts of Ph.D. Thesis in Biology, Kazan (1974).Google Scholar
  8. 8.
    F. G. Sitdikov,Zh. Evoluts. Biokhim.,17, No 6, 569–572 (1981).Google Scholar
  9. 9.
    J. Vlk,Physiol. Bohemoslov,30, No. 6, 497–503 (1981).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • F. G. Sitdikov
    • 1
  • T. A. Anikina
    • 1
  • R. I. Gil'mutdinova
    • 1
  1. 1.Department of Anatomy, Physiology, and Human Health ProtectionKazan' Pedagogic UniversityKazanUSSR

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