Adrenergic and cholinergic control on the heart in rat ontogenesis
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The concentrations of acetylcholine and norepinephrine and acetylcholinesterase activity in the myocardium as well as chronotropic cardiac response to exogenous mediators administered in increasing doses were studied in experiments on growing rats. The results indicate that the chronotropic response to norepinephrine decreases with age despite of increased intracardial concentration of norephinephrine. Cholinergic influence and myocardial reactivity to acetylcholine increase with age.
Key Wordsnorepinephrine acetylcholine acetylcholinesterase sensitivity reactivity
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