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Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 4, pp 1023–1024 | Cite as

Modification of ethylmethane sulfonate-induced mytagenesis with adrenaline

  • V. V. Semenov
  • M. Ya. Ibragimova
  • B. I. Barabanshchikov
Pharmacology and Toxicology
  • 26 Downloads

Abstract

Experiments withCrepis capillaris dry seeds show that pretreatment with adrenaline hydrochloride and adrenaline hydrotartrate significantly reduces the number of aberrations induced by the supermutagen ethylmethane sulfonate. The effective concentration ranges for adrenaline adrenaline hydrotartrate and hydrochloride are 10−1–10−7 M and 10−3–10−7 M, respectively. Adrenaline hydrochloride is more effective than adrenaline hydrotartrate (79.1vs. 65%, respectively).

Key Words

antimutagens mutagenesis receptor adrenaline 

References

  1. 1.
    M. D. Mashkovskii,Drugs [in Russian], Moscow (2985).Google Scholar
  2. 2.
    V. V. Roshchina,Acetylcholine and Biotransmitters in Plants [in Russian], Kazan' (1993).Google Scholar
  3. 3.
    V. V. Semenov, I. A. Studentsova, A. D. Durnev,et al., Vopr. Med. Khimii,40, No. 3, 48–51 (1994).PubMedGoogle Scholar
  4. 4.
    P. V. Sergeev and N. L. Shimanovskii,Receptors of Physiologically Active Substances [in Russian], Moscow (1987).Google Scholar
  5. 5.
    V. Yu. Urbakh,Biometrical Methods [in Russian], Moscow (1964).Google Scholar
  6. 6.
    M. F. El-Refai and J. H. Exton,Eur. J. Pharmacol.,62, 201–204 (1980).PubMedCrossRefGoogle Scholar
  7. 7.
    J. H. Exton,Mol. Cell Endocrinol.,23, 233–264 (1981).PubMedCrossRefGoogle Scholar
  8. 8.
    B. B. Hoffman and R. Lefkowitz,Annu. Rev. Pharmacol. Toxicol.,20, 581–608 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • V. V. Semenov
    • 1
  • M. Ya. Ibragimova
    • 1
  • B. I. Barabanshchikov
    • 1
  1. 1.Kazan' State Medical UniversityUSSR

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