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Effects of actovegin on the central nervous system during postischemic period

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In a rat model of 5-min clinical death caused by massive blood loss actovegin prevented the development of metabolic disorders induced by hypoxia and reoxygenation as well as the damage to the central nervous system in the early postresuscitation period. Intracarotid administration of actovegin increased the activity of reduction-oxidation enzymes, intensified aerobic metabolism of glucose, prevented lactate accumulation in the brain, reduced structural disorders in the central nervous system, and provided faster restoration of the major reflexes after a 5-min total ischemia.

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Authors and Affiliations

  1. Central Research Laboratory, Nizhni Novgorod Medical Academy, USSR

    G. A. Boyarinov, I. V. Mukhina, A. A. Penknovich, L. B. Snopova, Yu. V. Zimin, M. V. Balandina, A. M. Radaev, I. E. Skvortsova & N. N. Prodanets

  2. Department of Anesthesiology, Resuscitation, and Transfusiology, Military Medical Institute of the Federal Frontier Service, USSR

    G. A. Boyarinov, I. V. Mukhina, A. A. Penknovich, L. B. Snopova, Yu. V. Zimin, M. V. Balandina, A. M. Radaev, I. E. Skvortsova & N. N. Prodanets

  3. N. L. Pyatnitskii Municipal Hospital Nizhni Novgorod, USSR

    G. A. Boyarinov, I. V. Mukhina, A. A. Penknovich, L. B. Snopova, Yu. V. Zimin, M. V. Balandina, A. M. Radaev, I. E. Skvortsova & N. N. Prodanets

Authors
  1. G. A. Boyarinov
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  2. I. V. Mukhina
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  3. A. A. Penknovich
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  4. L. B. Snopova
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  5. Yu. V. Zimin
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  6. M. V. Balandina
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  7. A. M. Radaev
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  8. I. E. Skvortsova
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  9. N. N. Prodanets
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10, pp. 395–398, October, 1998

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Boyarinov, G.A., Mukhina, I.V., Penknovich, A.A. et al. Effects of actovegin on the central nervous system during postischemic period. Bull Exp Biol Med 126, 993–996 (1998). https://doi.org/10.1007/BF02447301

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  • DOI: https://doi.org/10.1007/BF02447301

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