Skip to main content
SpringerLink
Log in

Ultrastructural changes in the pancreas and their role in the pathogenesis of myocardial injury in endotoxin shock

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The pancreas in endotoxin shock is characterized by the hypoperfusion, prolonged cycle of acinar cell secretion, and activation of their lysosomal system. The rearrangements in the exocrine part of the gland involve the production of a myocardial depressant factor exerting a negative inotropic effect on the heart. Myocardial dysfunction is aggravated by myofibrillar contractures, myocytolysis, glycogenolysis, and circulatory disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. A. Bardakhch'yan,Pat. Fiziol., No. 6, 80–84 (1988).

    Google Scholar 

  2. E. A. Bardakhch'yan, T. V. Gordeeva-Gavrikova, and Yu. P. Cherepanov,Cor Vasa,20, No. 4, 322–325 (1978).

    Google Scholar 

  3. E. A. Bardakhch'yan and Yu. G. Kirichenko,Byull. Eksp. Biol. Med.,102, No. 7, 97–100 (1986).

    Google Scholar 

  4. E. A. Bardakhch'yan and E. I. Pal'chikova,Cor Vasa,29, No. 1, 64–69 (1987).

    Google Scholar 

  5. E. A. Bardakhch'yan and N. G. Kharlanova,Anest. Reanimatol., No. 6, 51–54 (1990).

    Google Scholar 

  6. E. A. Bardakhch'yan and N. G. Kharlanova,Kardiologiya,33, No. 3, 46–50 (1993).

    Google Scholar 

  7. A. S. Kanayan, N. K. Permyakov, R. K. Khandanyan, and G. A. Gevorkyan,Arkh. Patol., No. 5, 56–61 (1966).

    Google Scholar 

  8. O. V. Nikulin, B. A. Saakov, and E. A. Bardakhch'yan,Byull. Eksp. Biol. Med.,94, No. 12, 107–110 (1982).

    CAS  Google Scholar 

  9. N. K. Permyakov, A. E. Podol'skii, and G. P. Titova,Ultrastructural Analysis of Secretory Cycle of the Pancreas [in Russian], Moscow (1973).

  10. D. S. Sarkisov,Arkh. Patol., No. 4, 3–11 (1984).

    Google Scholar 

  11. V. V. Yaglov, L. I. Khananaev, and I. A. Mikhailyuk,Arkh. Anat.,88, No. 1, 65–70 (1986).

    Google Scholar 

  12. E. Gmaz-Nikulin, A. Nikulin, P. Plamenac,et al., J. Pathol.,135, No. 3, 223–236 (1981).

    Article  PubMed  CAS  Google Scholar 

  13. U. Haglund,Crit. Care Med.,21, No. 2, Suppl., 15–18 (1993).

    Article  Google Scholar 

  14. A. M. Lefer,Fed. Proc.,37, No. 13, 2734–2740 (1978).

    PubMed  CAS  Google Scholar 

  15. A. M. Lefer,Circ. Shock,1, No. 1, Suppl., 1–8 (1979).

    CAS  Google Scholar 

  16. A. M. Lefer,Klin. Wochenschr.,60, No. 14, 713–716 (1982).

    Article  PubMed  CAS  Google Scholar 

  17. E. Page and P. I. Pollimeni,Am. J. Pathol.,87, No. 1, 81–104 (1977).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathomorphology and Pathophysiology, Plague Control Institute, Rostov-on-Don

    E. A. Bardakhch'yan, N. G. Kharlanova & Yu. M. Lomov

Authors
  1. E. A. Bardakhch'yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. G. Kharlanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu. M. Lomov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 587–593, November, 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bardakhch'yan, E.A., Kharlanova, N.G. & Lomov, Y.M. Ultrastructural changes in the pancreas and their role in the pathogenesis of myocardial injury in endotoxin shock. Bull Exp Biol Med 126, 1164–1169 (1998). https://doi.org/10.1007/BF02447264

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02447264

Key Words

Search

Navigation