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Protective role of the free glucocorticoid pool in the development of autoimmune hemolytic anemia

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The development of autoimmune hemolytic anemia in NZB mice aged 2–3, 6–7, and 10–12 months is associated with decreased corticosterone and increased corticosteroid-binding globulin concentrations in the blood. An increase in the pool of free glucocorticoids induced by dexamethasone decelerates the autoimmune processes. (NZB×DBZ/2) F1 mice, which never develop the disease, are characterized by a high adrenal activity and a low blood level of corticosteroid-binding globulin. High level of free glucocorticoids is believed to prevent autoimmune reactions.

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Authors and Affiliations

  1. Department of Physiological Genetics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk

    A. Yu. Karyagina, V. M. Chesnokova, A. N. Ivanova, A. A. Tinnikov & L. N. Ivanova

Authors
  1. A. Yu. Karyagina
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  2. V. M. Chesnokova
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  3. A. N. Ivanova
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  4. A. A. Tinnikov
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  5. L. N. Ivanova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 572–575, November, 1998.

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Karyagina, A.Y., Chesnokova, V.M., Ivanova, A.N. et al. Protective role of the free glucocorticoid pool in the development of autoimmune hemolytic anemia. Bull Exp Biol Med 126, 1149–1151 (1998). https://doi.org/10.1007/BF02447259

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  • DOI: https://doi.org/10.1007/BF02447259

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