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Immediate and remote effects of antitumor drug on the morphology of rat liver

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments performed on rats have shown that a single intravenous injection of the antitumor preparations platidiam and pharmorubicine in the maximum tolerated dose cause morphological changes in the liver which are preserved for 3 months after platidiam and for 6 moths after pharmorubicine. Instability of reparative processes in the liver was revealed when the rats were poisoned with CCl4, 1, 3, and 6 months after administration of the cytostatics.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Siberian, USSR

    E. D. Gol'dberg, T. I. Fomina, T. V. Vetoshkina, T. Yu. Dubskaya, V. E. Gol'dberg & M. V. Filipova

Authors
  1. E. D. Gol'dberg
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  2. T. I. Fomina
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  3. T. V. Vetoshkina
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  4. T. Yu. Dubskaya
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  5. V. E. Gol'dberg
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  6. M. V. Filipova
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 561–564, November, 1998

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Gol'dberg, E.D., Fomina, T.I., Vetoshkina, T.V. et al. Immediate and remote effects of antitumor drug on the morphology of rat liver. Bull Exp Biol Med 126, 1140–1143 (1998). https://doi.org/10.1007/BF02447256

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  • DOI: https://doi.org/10.1007/BF02447256

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