Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 5, pp 1127–1128 | Cite as

Heat shockin vivo modulates cytotoxicity of xenobiotics

  • A. B. Egorova
  • T. A. Romanova
  • V. V. Ivanov
  • V. P. Nefedov
Biophysics and Biochemistry
  • 13 Downloads

Abstract

Heat shock was modeledin vivo for induction of cross-thermotolerance to acrylamide, a xenobiotic inductor of oxidative stress. Single hyperthermia (40–41°C, 25 min) reduced neuro- and hepatotoxicity of xenobiotic toxifying by phenobarbital-, but not methylcholanthrene-induced cytochrome P-450 isoforms (the hexenal test).

Key Words

heat shock xenobiotics cytochrome P-450 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • A. B. Egorova
    • 1
    • 2
    • 3
  • T. A. Romanova
    • 1
    • 2
    • 3
  • V. V. Ivanov
    • 1
    • 2
    • 3
  • V. P. Nefedov
    • 1
    • 2
    • 3
  1. 1.Krasnoyarsk State Medical AcademySiberian Division of the Russian Academy of SciencesSiberianUSSR
  2. 2.Krashoyarsk State AgrouniversitySiberian Division of the Russian Academy of SciencesSiberianUSSR
  3. 3.Krasnoyarsk Research CenterSiberian Division of the Russian Academy of SciencesSiberianUSSR

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