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Synthesis and hemodynamic effects of a new endothelin-converting enzyme inhibitor

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A new endothelin-converting enzyme inhibitor PP-35 including Nα-benzylsuccinyl group and Leu-Trp-OH dipeptide is synthesized. Similarly to phosphoramidon substance PP-35 abolishes elevation of systemic blood pressure and heart rate decrease in normotensive rats in response to bolus injection of big endothelin-1. Hemodynamic responses to endothelin-1 remain unchanged.

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References

  1. O. A. Gomazkov, V. F. Pozdnev, E. V. Kalinina,et al., Byull. Eksp. Biol. Med.,122, No. 9, 279–281 (1996).

    CAS  Google Scholar 

  2. E. V. Kalinina, V. F. Pozdnev, N. V. Komissarova, and O. A. Gomazkov,Biokhimiya,62, No. 3, 247–250 (1997).

    CAS  Google Scholar 

  3. K. Barnes, K. Shimada, M. Takahashi,et al., J. Cell. Sci.,109, 919–928 (1996).

    PubMed  CAS  Google Scholar 

  4. R. Bihovsky, B. Levinson, R. Loewi,et al., J. Med. Chem.,38, 2119–2129 (1995).

    Article  PubMed  CAS  Google Scholar 

  5. R. Corder and J. Vane,Biochem. Pharmacol.,49, 375–380 (1995).

    Article  PubMed  CAS  Google Scholar 

  6. P. Deprez, J. Guillaume, J. Dumas, and J.-P., Vevert,Bioorg. Med. Chem. Lett.,6, 2317–2322 (1996).

    Article  CAS  Google Scholar 

  7. P. Dispaquale, L. Valdes, V. Albano,et al., J. Cardiovasc. Pharmacol.,29, 202–208 (1997).

    Article  Google Scholar 

  8. S. Galatiusjensen, H. Wroblewski, C. Emmeluth,et al., Cardiovasc. Res.,32, 1148–1154 (1996).

    Article  CAS  Google Scholar 

  9. G. Gray and D. Webb,Pharmacol. Ther. 72, 109–148 (1996).

    Article  PubMed  CAS  Google Scholar 

  10. P. Kukkola, N. Bilci, W. Kozak,et al., Bioorg. Med. Chem. Lett.,6, 619–624 (1996).

    Article  CAS  Google Scholar 

  11. A. Morita, M. Nomizu, M. Okitsu,et al., FEBS Lett.,353, 84–88 (1994).

    Article  PubMed  CAS  Google Scholar 

  12. A. Patil, A. Freyer, D. Eggleston,et al., J. Nat. Prod.,60, 306–308 (1997).

    Article  PubMed  CAS  Google Scholar 

  13. R. Rhoten, Y. Comair, D. Shedid,et al., J. Neurosurg.,86, 101–108 (1997).

    Article  PubMed  CAS  Google Scholar 

  14. Y. Tsurumi, H. Uede, K. Hayashi,et al., J. Antibiot. (Tokyo), 48, 1066–1075 (1995).

    CAS  Google Scholar 

  15. A. Turner and L. Murphy,Biochem. Pharmacol.,51, 91–102 (1996).

    Article  PubMed  CAS  Google Scholar 

  16. M. Yangisawa, H. Kurihara, S. Kimura,et al., Nature,332, 411–415 (1988).

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow

    V. F. Pozdnev & O. A. Gomazkov

  2. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, USSR

    M. P. Davydova & N. A. Medvedeva

Authors
  1. V. F. Pozdnev
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  2. O. A. Gomazkov
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  3. M. P. Davydova
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  4. N. A. Medvedeva
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 526–529, November, 1998

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Pozdnev, V.F., Gomazkov, O.A., Davydova, M.P. et al. Synthesis and hemodynamic effects of a new endothelin-converting enzyme inhibitor. Bull Exp Biol Med 126, 1110–1112 (1998). https://doi.org/10.1007/BF02447247

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  • DOI: https://doi.org/10.1007/BF02447247

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