Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 5, pp 1095–1097 | Cite as

Modulating effect of μ-opiate receptor ligands on adrenergic stage in pathogenesis of stress-induced damage to the heart

  • Yu. B. Lishmanov
  • N. V. Naryzhnaya
  • Yu. G. Revinskaya
  • L. N. Maslov
General Pathology and Pathological Physiology

Abstract

The agonists of μ-opiate receptors, DAGO and DALDA, prevent stress-induced enhancement of99mTc-pyrophosphate accumulation in the myocardium, which attests to cardioprotective activity of these opioids. This phenomenon is presumably related to modulating effect of these agents on the adrenergic stage in pathogenesis of stress-induced damage to the heart.

Key Words

opiate receptors stress catecholamines 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • Yu. B. Lishmanov
    • 1
  • N. V. Naryzhnaya
    • 1
  • Yu. G. Revinskaya
    • 1
  • L. N. Maslov
    • 1
  1. 1.Department of Experimental Cardiology, Institute of CardiologySiberian Division of the Russian Academy of Medical SciencesTomsk

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