Skip to main content
SpringerLink
Log in

The role of age-related factors in the effect of long-term perfusion on the contractility of isolated heart

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on isolated hearts of mature and senescent rats showed that in mature rats the heart contractility decreased to a greater extent during the initial hours of a long-term perfusion, but in mature heart tolerance to perfusion was higher. Creatine phosphokinase activity drastically increased in the perfusate of senescent hearts and changed insignificantly in the perfusate of mature hearts. In mature rats a long-term perfusion was accompanied by activation of Na,K-ATPase, which was prevented by actinomycin D. Transfer of perfusate in the donor-recipient double-heart experiments with prior administration of actinomycin D showed that long-term perfusion induces the synthesis of a regulator factor (inverter) in the heart of mature rats which modulates myocardial contractility. This regulator peptide contributes to adaptive potency of the heart in mature animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. M. Lobanok,Regulation of Contractility in the Heart [in Russian], Minsk, (1994).

  2. T. G. Sazontova,Byull Eksp. Biol. Med.,102, No. 11, 685–687 (1986).

    CAS  Google Scholar 

  3. V. V. Frol'kis,Dokl. Ross. Akad. Nauk,324, No. 1, 229–232 (1992).

    Google Scholar 

  4. V. V. Frol'kis, V. V. Bezrukov, and O. K. Kul'chitskii,Aging and Expermental Age-Related Pathology of Cardiovascular System [in Russian], Kiev (1994).

  5. N. K. Furkalo, V. V. Bratus', and R. A. Frol'kis,Coronary Insufficiency: Myocardial Blood Supply, Function, and Metabolism [in Russian], Kiev (1986).

  6. M. M. Bradford,Anal. Biochem.,72, 248–254 (1976).

    Article  PubMed  CAS  Google Scholar 

  7. E. L. Fallen, W. C. Elliot, and R. Gorlin,J. Appl. Physiol.,22, No. 4, 836–839 (1967).

    PubMed  CAS  Google Scholar 

  8. W. Rathburn and V. Betlach,Anal. Biochem.,28, No. 2, 436–445 (1969).

    Article  Google Scholar 

  9. J. D. Robinson and M. S. Flashner,Biochim. Biophys. Acta.,549, No. 2, 145–176 (1979).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Physiology, Institute of Gerontology, Ukrainian Academy of Medical Sciences, Kiev

    V. V. Frol'kis & O. V. Beruk

Authors
  1. V. V. Frol'kis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. V. Beruk
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 7, pp. 505–509, November, 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Frol'kis, V.V., Beruk, O.V. The role of age-related factors in the effect of long-term perfusion on the contractility of isolated heart. Bull Exp Biol Med 126, 1091–1094 (1998). https://doi.org/10.1007/BF02447241

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02447241

Key Words

Search

Navigation