Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 6, pp 1231–1234 | Cite as

Effect of the γ-aminobytyric acid derivative TZ-50-2 on systemic and cardiac hemodynamics and size of myocardial necrosis

  • P. A. Galenko-Yaroshevskii
  • O. S. Medvedev
  • A. V. Uvarov
  • A. N. Mingalev
  • A. Yu. Turovaya
  • Z. I. Tyukhteneva
Pharmacology and Toxicology
  • 21 Downloads

Abstract

The linear derivative of γ-aminobutyric acid TZ-50-2 (4-hydroxy-3-benzylamino-N-benzyl-butanamide hemisuccinate) stimulates coronary circulation (particularly in the left ventricular myocardium) in intact cats, decreases vascular resistance, stimulates the blood flow in ischemic endo- and mesocardium, and decreases (similarly as perlinganite, obsidan, and finoptin) the necrotic zone area in experimental myocardial infarction.

Key Words

γ-aminobutyric acid cardiohemodynamics ischemia myocardial infarction 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    S. A. Afanas'ev, E. D. Alekseeva, I. B. Bardamova,et al., Eksp. Klin. Farmakol.,56, No. 4, 24–26 (1994).Google Scholar
  2. 2.
    M. L. Belen'kii,Elements of Quantitative Assessment of Pharmacologic Effect [in Russian], Leningrad (1963).Google Scholar
  3. 3.
    P. A. Galenko-Yaroshevskii, S. A. Kryzhanovskii, A. V. Uvarov,et al., Byull. Eksp. Biol. Med.,124, No. 11, 533–536 (1997).Google Scholar
  4. 4.
    S. V. Gatsura, in:Pharmacology of Cardiotropic Drugs [in Russian], Moscow (1984), pp. 82–86.Google Scholar
  5. 5.
    M. D. Mashkovskii,Drugs [in Russian], Kharkov (1997), Vol. 1, p. 262.Google Scholar
  6. 6.
    O. S. Medvedev, O. S. Murashev, F. E. Meertsuk, and S. F. Dugin,Fiziol. Zh. SSSR,72, No. 2, 253–256 (1986).PubMedGoogle Scholar
  7. 7.
    E. V. Montsevichiute-Eringiene,Pat. Fiziol., No. 4, 71–78 (1984).Google Scholar
  8. 8.
    Yu. M. Ostrogorodskii, N. I. Afonskaya, N. M. Cherpochenko,et al., Byull. Eksp. Biol. Med.,92, No. 8, 56–58 (1981).Google Scholar
  9. 9.
    V. N. Perfilova and V. V. Kovtun,Fundamental Research as the Basis for Creating Drugs [in Russian], Volgograd (1995).Google Scholar
  10. 10.
    L. T. Pimenov, A. D. Churkin, and A. V. Ezhov,Cardiologiya,35, No. 11, 30–38 (1995).Google Scholar
  11. 11.
    P. V. Sergeev, P. A. Galenko-Yaroshevskii, and N. L. Shimanovskii,Essays of Biochemical Pharmacology [in Russian], Moscow (1996).Google Scholar
  12. 12.
    Z. I. Tyukhteneva, L. A. Badovskaya, M. A. Tlekhusezh,et al., Byull. Izobret., No. 15, 276 (1990).Google Scholar
  13. 13.
    I. K. Shkhvatsabaya, in:Manual of Cardiology [in Russian], Moscow (1982), Vol. 3, pp. 5–49.Google Scholar
  14. 14.
    L. Alps,Acta Biol. Med. Gern.,35, No. 3, 115–117 (1983).Google Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • P. A. Galenko-Yaroshevskii
    • 1
    • 2
  • O. S. Medvedev
    • 1
    • 2
  • A. V. Uvarov
    • 1
    • 2
  • A. N. Mingalev
    • 1
    • 2
  • A. Yu. Turovaya
    • 1
    • 2
  • Z. I. Tyukhteneva
    • 1
    • 2
  1. 1.Department of PharmacologyKuban State Medical AcademyKrasnodar
  2. 2.Laboratory of Pharmacology, Research and Production Cardiology ComplexMinistry of Health of RussiaMoscow

Personalised recommendations