Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 6, pp 1203–1204 | Cite as

Biotransformation of hepatic xenobiotics in rats with various resistance to hypoxia exposure to after cold

  • O. R. Grek
  • Yu. P. Gichev
  • E. O. Guseva
  • V. I. Sharapov
General Pathology and Pathological Physiology
  • 23 Downloads

Abstract

Hepatic monooxygenase activity was studied in rats with various resistance to hypoxia during adaptation to cold. Cold-induced change in the concentrations of cytochromes P-450 and b5 and the activity of microsomals metabolism of amidopyrine and aniline were shown to be associated with individual resistance to hypoxia. The content of microsomal cytochromes in highly resistant rats did not change on the fifth day of cold exposure. However, the intensity of metabolic reactions decreased. In low-resistance rats, a cold-induced decrease in the concentration of the cytochromes was not accompanied by significant changes in metabolic rates of amidopyrine and aniline.

Key Words

individual resistance to hypoxia hepatic monooxygenases cold adaptation 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • O. R. Grek
    • 1
    • 2
  • Yu. P. Gichev
    • 1
    • 2
  • E. O. Guseva
    • 1
    • 2
  • V. I. Sharapov
    • 1
    • 2
  1. 1.Laboratory of Clinical Problems of Ecology, Institute of Regional Pathology and PathomorphologySiberian Division of the Russian Academy of Medical SciencesNovosibirsk
  2. 2.Department of PharmacologyNovosibirsk Medical InstituteNovosibirskUSSR

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