Abstract
The calcium antagonist verapamil, a P-glycoprotein inhibitor, affects the growth of human tumor transplants under the capsule of the animal kidney with an oscillating-type dose-effect dependence. The maximal positive effect of verapamil is tumor regression and the maximal negative effect stimulation of transplant growth. In 3 out of 6 cases (gastric adenocarcinoma) verapamil at 9 mg/kg injected 0.5 h prior to vincristine inhibited tumor resistance to the latter. These data offer promise for increasing the effectiveness of chemotherapy in patients with cancer of the stomach by means of chemotherapy combined with P-glycoprotein blockers in doses determined for each individual.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 681–683, June, 1996
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Storozhenko, I.V., Sergeeva, N.S., Chissov, V.I. et al. Effect of verapamil on the growth and vincristine sensitivity of human tumors transplanted under the mouse kidney capsule. Bull Exp Biol Med 121, 615–617 (1996). https://doi.org/10.1007/BF02447133
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DOI: https://doi.org/10.1007/BF02447133