Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 6, pp 599–601 | Cite as

The effect of various incorporated doses of131I on immunological reactions of the organism

  • A. S. Solov'ev
  • N. V. Gurova
  • N. E. Shchebnikova
Microbiology and Immunology
  • 14 Downloads

Abstract

Administration of radioisotope131I at 148 kBq/g body weight results in an inhibition of the primary immune response and in a decrease of proliferating activity of mouse lymphocytes in response to alloantigen stimulation. The number of antibody-producing spleen cells for immunization of mice with sheep erythrocytes diminished after administration of131I at 74 kBq/g animal weight.

Key Words

lymphocyte immunity immune system 131I 

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References

  1. 1.
    B. D. Brondz, G. I. Khachikyan, G. I. Drizlikh, and A. V. Andreev,Byull. Eksp. Biol. Med.,83, No. 6, 723–725 (1977).CrossRefGoogle Scholar
  2. 2.
    I. Ya. Vasilenko, in:Kinetics of Metabolism and Biological Action of Radioactive Iodine Isotopes [in Russian], Moscow (1989), pp. 29–41.Google Scholar
  3. 3.
    Yu. I. Moskalev,Ibid., pp. 7–28.Google Scholar
  4. 4.
    D. G. Rokhlin and V. P. Zadvornova,Ionizing Radiation in the Diagnosis and Treatment of Thyroid Cancer [in Russian], Leningrad (1972).Google Scholar
  5. 5.
    V. V. Khorobrykh, L. V. Pronin, A. F. Kirkin, and A. V. Sanin,Immunologiya, No. 3, 76–79 (1983).Google Scholar
  6. 6.
    N. K. Jerne and A. A. Nordin,Science,140, 405–407 (1963).Google Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • A. S. Solov'ev
    • 1
  • N. V. Gurova
    • 1
  • N. E. Shchebnikova
    • 1
  1. 1.Department of Medical BiologySmolensk Medical AcademySmolenskUSSR

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