Abstract
Some biochemical mechanisms of the protective effect of cordaron with respect to strophanthin K cardiotoxicity in modeled cardiac failure are experimentally studied in random-bred male albino mice. Strophanthin K is shown to aggravate the disturbances in free and total activity of β-glucosidase and in lysosome membrane permeability in the heart that are characteristic of this pathology. In comparison with the toxic dose of cardiac glycoside, cordaron has an opposite effect on the functional state of the myocardial lysosome system.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 645–647, June, 1996
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Galenko-Yaroshevskii, P.A., Lemkina, S.M. & Kostin, Y.V. Correction of altered β-glucosidase activity induced by the toxic effect of strophanthin K and modeled cardiac decompensation with cordaron. Bull Exp Biol Med 121, 581–583 (1996). https://doi.org/10.1007/BF02447123
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DOI: https://doi.org/10.1007/BF02447123