Abstract
Sedatin, an analog of the opioid peptide dermorphin, which is a mixed μ- and δ-receptor agonist, had no effect on DNA synthesis and mitotic activity in the corneal or lingual epithelium of rats in a single dose 10 μg/kg, but stimulated cell division in both epithelia in a single dose of 100 μg/kg and in the 10 μg/kg dose administered either once daily over a 21-day period or just once after a single injection of the opiate receptor antagonist naloxone.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 641–644, June, 1996
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Fleishman, M.Y., Kuznetsov, A.V., Radivoz, M.I. et al. Effect of sedatin, a synthetic dermorphin analog, on cell division in the corneal and lingual epithelia of rats. Bull Exp Biol Med 121, 578–580 (1996). https://doi.org/10.1007/BF02447122
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DOI: https://doi.org/10.1007/BF02447122