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Evaluation of the control function of interstitial osmolarity in coronary autoregulation

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Abstract

A control mechanism for the control of coronary blood flow (especially coronary autoregulation), presuming that interstitial osmotic pressure determines vascular resistance, was critically examined. A theoretical model of the control mechanism was made and the most important parameters of this theoretical model were estimated from published data. The parameters are the slope of coronary autoregulation curves, the sensitivity of coronary resistance to plasma oncotic pressure and capillary resistance. It appeared that the gains of this control loop were not large enough to allow for a dominant role of interstitial osmolarity in coronary autoregulation.

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Authors and Affiliations

  1. Section for Risk & Reliability Analysis, Division of Mechanical, Metallurgical & Chemical Testing, N. V. Kema, Arnhem, The Netherlands

    G. Heslinga

  2. Laboratory for Measurement & Control, Faculty of Mechanical Engineering & Marine Technology, Delft University of Technology, Delft, The Netherlands

    H. G. Stassen

  3. Department of Medical Physics, Faculty of Medicine, University of Amsterdam, AMC Bouwdeel L/O, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    J. A. E. Spaan

Authors
  1. G. Heslinga
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  2. H. G. Stassen
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  3. J. A. E. Spaan
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Heslinga, G., Stassen, H.G. & Spaan, J.A.E. Evaluation of the control function of interstitial osmolarity in coronary autoregulation. Med. Biol. Eng. Comput. 29, 212–216 (1991). https://doi.org/10.1007/BF02447110

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  • DOI: https://doi.org/10.1007/BF02447110

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