Abstract
Culturing of postimplantation embryos of C57B1/6 and DBA mice differing in the ability to biotransform 3,4-benz(a)pyrene, reciprocal crossing of these animals, and transfer of preimplantation embryos into sham-pregnant females is used to model different genetic states by the Ah locus in the mother-fetus system. The role of metabolic factors at the early stages of embryogenesis in the realization of embryo- and genotoxic effects of 3,4-benz(a)pyrene is evaluated.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 449–452, October, 1996
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Popov, V.B. The role of genetic differences in the mother—Fetus system in biotransformation of proteratogens. Bull Exp Biol Med 122, 1041–1043 (1996). https://doi.org/10.1007/BF02447031
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DOI: https://doi.org/10.1007/BF02447031